journal article·2019-08-09

Microengineered Emulsion-to-Powder Technology for the High-Fidelity Preservation of Molecular, Colloidal, and Bulk Properties of Hydrogel Suspensions

Amir Sheikhi, Donatella Di Lisa, Joseph de Rutte, Outman Akouissi, Dino Di Carlo, Ali Khademhosseini

ACS Applied Polymer Materials· Volume 1· Issue 8
Publisher page

Abstract

Aqueous micro/nanogel suspensions remain difficult to sterilize, store, and ship. Current techniques such as freeze-drying and spray-drying have noticeably failed to preserve the structure of gel particles undergoing drying. We invented the microengineered emulsion-to-powder (MEtoP) technology via which a dispersed phase is stabilized and protected in an engineered oil/surfactant continuous phase, followed by freezing and lyophilization. This facile method converts colloidal systems, particularly annealable hydrogel suspensions, to powders that readily revive their properties upon resuspension. The MEtoP technology may open new horizons for soft material processing and set the stage for the high-fidelity conversion of colloids to powders with defined particle distributions for a broad spectrum of advanced applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: 3D Printing in Biomedical Research · Microencapsulation and Drying Processes · Advanced Drug Delivery Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, Los Angeles, California 90095, United States

Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, United States

California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095, United States

Department of Informatics, Bioengineering, Robotics and System Engineering, University of Genova, Via Opera Pia 13, 16145 Genova, Italy

Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90024, United States

Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, United States

Funding

Canadian Institutes of Health Research · National Institutes of Health · Presidential Early Career Award for Scientists and Engineers

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