journal article·2021-10-08

Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted In Vivo Inflammation Imaging

Shangyu Chen, Wansu Zhang, Xinyue Jiang, Yaqi Guo, Pengfei Sun, Wenjun Wang, Quli Fan, Wei Huang

ACS Applied Polymer Materials· Volume 3· Issue 10
Publisher page

Abstract

Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China

Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan 430071, China

Key Lab of Optical Communication Science and Technology of Shandong Province & School of Physics Science and Information Engineering, Liaocheng University, Liaocheng 252059, China

Frontiers Science Center for Flexible Electronics (FSCFE), MIIT Key Laboratory of Flexible Electronics (KLoFE), Northwestern Polytechnical University, Xi’an 710072, China

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Postgraduate Research and Innovation Project of Jiangsu Province

References (36)

Show source-provided references
1. 10.1038/nmat447610.1038/nmat4476 ↗
2. 10.1038/s41551-016-001010.1038/s41551-016-0010 ↗
3. 10.1002/adma.20180239410.1002/adma.201802394 ↗
4. 10.1002/anie.20150747310.1002/anie.201507473 ↗
5. 10.1039/c8sc01153b10.1039/c8sc01153b ↗
6. 10.1002/adfm.20190148010.1002/adfm.201901480 ↗
7. 10.1038/s41467-019-09043-x10.1038/s41467-019-09043-x ↗
8. 10.1002/anie.20130734610.1002/anie.201307346 ↗
9. 10.1002/adma.20160549710.1002/adma.201605497 ↗
10. 10.1002/adma.20180076610.1002/adma.201800766 ↗
11. 10.1021/acsnano.0c0224910.1021/acsnano.0c02249 ↗
12. 10.1038/s41467-018-08092-y10.1038/s41467-018-08092-y ↗
13. 10.1021/acsmaterialslett.9b0048010.1021/acsmaterialslett.9b00480 ↗
14. 10.1021/jacs.9b1004310.1021/jacs.9b10043 ↗
15. 10.1002/adfm.20180495610.1002/adfm.201804956 ↗
16. 10.1002/smll.20180554910.1002/smll.201805549 ↗
17. 10.1002/adma.20180254610.1002/adma.201802546 ↗
18. 10.1021/jacs.7b1033410.1021/jacs.7b10334 ↗
19. 10.1039/c7sc00251c10.1039/c7sc00251c ↗
20. 10.1021/acs.jchemed.5b0048310.1021/acs.jchemed.5b00483 ↗
21. 10.1039/c8cc08096h10.1039/c8cc08096h ↗
22. 10.1038/s41467-021-22686-z10.1038/s41467-021-22686-z ↗
23. 10.1016/j.biomaterials.2015.04.00110.1016/j.biomaterials.2015.04.001 ↗
24. 10.1002/adma.20170685610.1002/adma.201706856 ↗
25. 10.1021/acsnano.0c0382410.1021/acsnano.0c03824 ↗
26. 10.1039/c6cc06176a10.1039/c6cc06176a ↗
27. 10.1002/anie.20200856410.1002/anie.202008564 ↗
28. 10.1016/j.biomaterials.2020.12036510.1016/j.biomaterials.2020.120365 ↗
29. 10.1002/anie.20150364010.1002/anie.201503640 ↗
30. 10.1016/j.nantod.2020.10089310.1016/j.nantod.2020.100893 ↗
31. 10.1039/c3py00605k10.1039/c3py00605k ↗
32. 10.1002/anie.20180881110.1002/anie.201808811 ↗
33. 10.1002/adfm.20200835610.1002/adfm.202008356 ↗
34. 10.1002/anie.20200788610.1002/anie.202007886 ↗
35. 10.1016/j.biomaterials.2021.12091610.1016/j.biomaterials.2021.120916 ↗
36. 10.1021/acs.nanolett.8b0228610.1021/acs.nanolett.8b02286 ↗