DataVXACS Applied Polymer MaterialsPaper
journal article·2022-12-09

Molecularly Imprinted Polymer Based on Carboxymethylcellulose/Graphene Oxide Composites for Selective Adsorption of Hydroxycamptothecin

Fang Nie, Chunying Li, Naveed Ahmad, Zhanyu Yuan, Yulian Tan, Yanwei Xu, Chunjian Zhao

ACS Applied Polymer Materials· Volume 4· Issue 12
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Source abstract

Abstract

Molecularly imprinted polymers based on carboxymethylcellulose/graphene oxide composites (CMC/GO@MIPs) were prepared using surface molecular imprinting technology for the adsorption of hydroxycamptothecin (HCPT). Using molecular simulations, methacrylic acid was selected as a suitable monomer via a preliminary green scheme. The structure and adsorption properties of CMC/GO@MIPs were investigated through various characterization methods and adsorption experiments. The adsorption mechanism was examined using an adsorption model. The Langmuir isotherm model and pseudo-second-order kinetic model matched well with the adsorption results, with a maximum adsorption capacity of 62.92 mg/g. Adsorption equilibrium was achieved within 30 min. Further, CMC/GO@MIPs exhibited excellent selectivity for HCPT (imprinting factor of 2.60) and good recyclability; the adsorption capacity decreased by only 10.50% after seven adsorption–desorption cycles. The purity of HCPT was 50.94% after separation in the actual sample. CMC/GO@MIPs prepared in this study are simple and convenient to use and display high specificity, extraction efficiency, stability, and reusability for the separation and enrichment of HCPT. This study provides a method for the separation and purification of HCPT in Camptotheca acuminata Decne and is an important reference for the separation, enrichment, and purification of natural components present in complex plant matrices.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsComposites

OpenAlex topics: Mesoporous Materials and Catalysis · Analytical chemistry methods development · Analytical Chemistry and Chromatography

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin150040, China

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin150040, China

Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin150040, China

Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Harbin150040, China

Department of Chemistry, Division of Science and Technology, University of Education, Lahore54660, Pakistan

Hisun Pharmaceutical (Hangzhou) Co., Ltd., No 1, Road, Xukou Town, Fuyang District, Hangzhou311404, China

Funding

Central University Basic Research Fund of China · National Natural Science Foundation of China · Higher Education Discipline Innovation Project · Heilongjiang Touyan Innovation Team Program

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