DataVXACS Applied Polymer MaterialsPaper
journal article·2022-04-08Open access

Tetracycline-Loaded Electrospun Poly(l-lactide-co-ε-caprolactone) Membranes for One-Step Periodontal Treatment

Thannaphat Jenvoraphot, Boontharika Thapsukhon, Donraporn Daranarong, Robert Molloy, Chayarop Supanchart, Suttichai Krisanaprakornkit, Paul D. Topham, Brian Tighe, Anisa Mahomed, Winita Punyodom

ACS Applied Polymer Materials· Volume 4· Issue 4
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Source abstract

Abstract

In this research, a one-step periodontal membrane, with the required function and properties, has been designed as an alternative method of tissue regenerative treatments. Designed nanoporous prototypes from poly(l-lactide-co-ε-caprolactone) (PLCL, 70:30 mol %) were fabricated by electrospinning, denoted as S-PLCL. They were subsequently loaded with tetracycline (TC) in order to enhance periodontal regeneration and deliver an anti-inflammatory and antibiotic drug. It was found that TC loading did not have any significant effect on the fiber diameter but did increase hydrophilicity. With the increase in TC loading, the water vapor permeability (WVP) of the S-PLCL membrane decreased within the range of 31–56% when compared with neat S-PLCL membranes, while in the solvent-cast film (F-PLCL), no significant change in WVP was observed. Moreover, S-PLCL demonstrated a controllable slow release rate of TC. S-PLCL loaded with 1500 μg/mL of TC showed a release concentration of 30 ppm over a certain time period to promote greater levels of human oral fibroblast and human oral keratinocyte cell proliferation and plaque inhibition. In conclusion, a TC-loaded S-PLCL fibrous membrane has been designed and fabricated to provide the ideal conditions for cell proliferation and antibiotic activity during treatment, outperforming nonfibrous F-PLCL loaded with TC at the same concentration.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Periodontal Regeneration and Treatments · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

Division of Chemistry, School of Science, University of Phayao, Mae Ka, Phayao 56000, Thailand

Science and Technology Research Institute, Chiang Mai University, Chiang Mai 50200, Thailand

Materials Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand

Department of Oral Biology and Oral Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand

Aston Institute of Materials Research, Aston University, Aston Triangle, Birmingham B4 7ET, U.K.

Funding

Office of National Higher Education Science Research and Innovation Policy Council · European Commission · Center of Excellence for Innovation in Chemistry · Center of Excellence in Materials Science and Technology, Chiang Mai University

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