DataVXACS Applied Polymer MaterialsPaper
journal article·2020-09-11

Hydrogen Sulfide-Responsive Self-Assembled Nanogel

Peng-Hao Hsu, Riku Kawasaki, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Atsushi Ikeda, Adah Almutairi

ACS Applied Polymer Materials· Volume 2· Issue 9
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Source abstract

Abstract

Hydrogen sulfide (H2S) is a signaling molecule whose overexpression is identified in various cancers. Despite the flourishing research of H2S-responsive nanomaterials, the development of H2S-responsive nanogels (NGs) has not been attempted yet. Here we report, for the first time, H2S-responsive NG, which was formulated from H2S-responsive cholesterol-modified dextran (SC-Dex) through self-assembly. H2S induces the dissociation of cholesterols from the dextran backbone of SC-Dex via reduction of aryl azide and the subsequent 1,4-rearrangement. In the presence of H2S, SC-Dex NGs show swelling behavior and controlled release of encapsulated protein. This NG might show potential applications as a H2S-responsive drug delivery system.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Sulfur Compounds in Biology · Nanoplatforms for cancer theranostics · Fibroblast Growth Factor Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

Funding

Air Force Office of Scientific Research · Japan Society for the Promotion of Science · TOYOBO Biotechnology Foundation

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