DataVXACS Applied Polymer MaterialsPaper
journal article·2021-02-12Open access

Cholate Conjugated Polymeric Amphiphiles as Efficient Artificial Ionophores

Subhasish Sahoo, Jawad ur Rehman, Muhammad Raza Shah, Priyadarsi De, Paolo Tecilla

ACS Applied Polymer Materials· Volume 3· Issue 2
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Source abstract

Abstract

A family of amphiphilic copolymers containing hydrophobic cholate pendants has been prepared by copolymerization of cholic acid-based monomer 2-(methacryloxy)-ethyl cholate (MAECA) with polyethylene glycol methyl ether methacrylate (PEGMA). The polymers differ for the content of MAECA that increases from 0 to 35%. The copolymers partition within liposomes and display potent ionophoric activity forming large pores in the membrane and allowing the leakage of small inorganic ions (H+, Na+) and of large polar organic molecules (calcein). Their activity is strictly correlated to the content of cholic acid subunits, increasing as the fraction of cholate moiety increases.
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Research context

Polymers

OpenAlex topics: Molecular Sensors and Ion Detection · Luminescence and Fluorescent Materials · Supramolecular Chemistry and Complexes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Polymer Research Centre and Centre for Advanced Functional Materials, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, West Bengal 741246, India

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Sindh 75270, Pakistan

Department of Chemical and Pharmaceutical Sciences, University of Trieste, via Giorgieri 1, I-34127 Trieste, Italy

Funding

Science and Engineering Research Board · H2020 Marie Sklodowska-Curie Actions · Department of Science and Technology, Ministry of Science and Technology

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