Protective Effect of Composite Hydrogel Based on Hydroxypropyl Trimethylammonium Chloride Chitosan on Skin Photodamage
Source abstract
Abstract
Long-term or excessive exposure to UV light can lead to sunburn, erythema, melanin deposition, inflammation, and even skin cancer. This study used composite hydrogels with N-2-hydroxypropyl trimethylammonium chloride chitosan (N-2-HACC) and hyaluronic acid (HA) as carriers. In addition, ellagic acid (EA) and proanthocyanidins (PC) as functionalized materials were prepared. The infrared results show that the N-2-HACC/HA/EA/PC hydrogel is formed by N-2-HACC connecting with HA by electrostatic interaction, and HA forms hydrogen bonds between EA and PC. The in vitro antioxidant results show that EA and PC have different clearance efficiency of DPPH and superoxide anion radicals at different pH values. Thus, they have complementary effects on antioxidant properties. The cumulative release results demonstrate that the hydrogels had an excellent slow-release rate at different pHs. The animal experiments reveal that N-2-HACC/HA/EA/PC could restore the consumption of antioxidant enzymes induced by UVB irradiation and inhibit matrix metalloproteinase 1. N-2-HACC/HA/EA/PC can inhibit UVB-induced histological damage, such as epidermal thickening, collagen fiber, and elastic fiber destruction. N-2-HACC/HA/EA/PC has a significant photoprotective effect by protecting the activities of superoxide dismutase, catalase, and glutathione peroxidase and inhibiting the activity of inflammatory factors. N-2-HACC/HA/EA/PC composite hydrogel system shows comprehensive performance. Its ability to scavenge free radicals may act as an antioxidant to protect mice from skin cancer.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Skin Protection and Aging · Phytochemicals and Antioxidant Activities · Pomegranate: compositions and health benefits
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Chemical Engineering Process and Technology for High−Efficiency Conversion, College of Chemistry and Materials Science, School of Life Science, Heilongjiang University, Harbin150080, China
Institute of Nanobiomaterials and Immunology, School of Life Science, Taizhou University, Taizhou318000, China
Funding
Taizhou Municipal Science and Technology Bureau · National Natural Science Foundation of China · Department of Education of Zhejiang Province · Natural Science Foundation of Zhejiang Province
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