Construction of Curcumin-Loaded Hydrogels for Treatment of Traumatic Brain Injury
Source abstract
Abstract
Traumatic brain injury (TBI) is a common clinical disease, and the current hyperbaric oxygen and hypothermia therapy are suboptimal. Traumatic brain injuries were accompanied by acute inflammatory reactions, brain edema, neuron damage, and the destruction of blood–brain barrier. Herein, curcumin-loaded lysine/poly(ethylene glycol) diacrylate (PEGDA) hydrogels were constructed via Michael addition for traumatic brain injury treatments. The curcumin-loaded lysine/PEGDA hydrogels were injected into brain injury defect sites with complex anatomical and irregular structures. The real-time therapeutic effects of the curcumin-loaded hydrogels were evaluated by magnetic resonance imaging (MRI). Curcumin-loaded hydrogels can inhibit the inflammatory reaction and promote nerve repair. The curcumin-loaded hydrogel could provide a promising strategy for traumatic brain injury treatments.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Traumatic Brain Injury and Neurovascular Disturbances · Heme Oxygenase-1 and Carbon Monoxide · S100 Proteins and Annexins
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, Nantong 226001, China
Funding
Natural Science Foundation of Shandong Province
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