DataVXACS Applied Polymer MaterialsPaper
journal article·2024-04-12Open access

In Situ Biofabrication of Microbial Cellulose Capsules Carrying Cubosomes: Toward Colon Targeted Multidrug Delivery

Filipe V. Ferreira, Nazanin Z. Ezazi, Caio G. Otoni, Ana Carolina Aguiar, Jhonatan R. O. Bianchi, João H. Lopes, Danilo M. dos Santos, Luiz G. Greca, Hernane S. Barud, Hélder A. Santos, Orlando J. Rojas, Luiz Henrique Capparelli Mattoso

ACS Applied Polymer Materials· Volume 6· Issue 7
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Source abstract

Abstract

The colon is a main absorption site (nutrients and drugs) and a target for oral therapeutic delivery. However, the latter is challenged by the fact that most drugs degrade during transit in the gastrointestinal tract (GIT). Herein, we rationally designed a universal controlled-release system based on cubosomes contained in microbial nanocellulose capsules that enabled oral administration and pH-triggered delivery of bioactives. We show that the bicontinuous cubosome structure allows the simultaneous incorporation of drugs with differing polarity or surface energy. Furthermore, the multidrug cubosomes combined with the cellulose carrier by in situ biofabrication was demonstrated as a route toward multicomponent 3D capsules with added protection in the GIT. The obtained capsules were subsequently coated with sodium alginate to enable responsiveness, achieving dual cargo-controlled release and site-specific administration. In sum, we successfully engineered pH-responsive, nontoxic microcapsules as a versatile platform for colon-targeted multidrug delivery.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Advanced Cellulose Research Studies · Advanced Drug Delivery Systems · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Embrapa Instrumentation, Nanotechnology National Laboratory for Agriculture (LNNA), 13561-206 São Carlos, SP, Brazil

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 00100, Finland

Department of Health Technology, Technical University of Denmark, Ørsteds Plads 345C, 2800Kgs. Lyngby, Denmark

Graduate Program in Materials Science and Engineering (PPGCEM), Department of Materials Engineering (DEMa), Federal University of São Carlos (UFSCar), 13565-905 São Carlos, SP, Brazil

School of Chemical Engineering, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil

Biomaterials and Biointerfaces Lab (BBLab), Department of Chemistry, Division of Fundamental Sciences (IEF), Aeronautics Institute of Technology (ITA), 12228-900 Sao Jose dos Campos-SP─Brazil

Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, FI-00076 Espoo, Finland

Cellulose & Wood Materials Laboratory, Swiss Federal Laboratories for Materials Science and Technology (EMPA), Dübendorf 8600, Switzerland

Biopolymers and Biomaterials Laboratory (BIOPOLMAT), University of Araraquara (UNIARA), Araraquara, 14801-340 São Paulo, Brazil

Department of Biomaterials and Biomedical Technology, University Medical Center Groningen, University of Groningen, Groningen 9713 AV, The Netherlands

Departments of Chemical & Biological Engineering, 2360 East Mall; Chemistry, 2036 Main Mall, and Wood Science, 2424 Main Mall, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada

Funding

Canada Foundation for Innovation · Canada Research Chairs · Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico · Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo · Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior

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