Mn(II) 3D Coordination Framework with Mixed 5-Aminoisophthalato and Pyridyl-isonicotinoyl Hydrazone Bridges: Structure, Electrical Conductivity, Anticancer Activity, and Drug Delivery

A 3D coordination polymer of Mn(II), [Mn 2 (aisp) 3 (pcih) 2 (solvent)] n ( CP1 ) ( pcih = pyridine-4-carboxaldehyde isonicotinoyl hydrazine and H 2 aisp = 5-aminoisophthalic acid), was constructed by doubly heterobridging ligands and was characterized by single-crystal X-ray diffraction measurements. The noncovalent forces (H-bonding, π···π interactions) bring robustness and stability (thermal and chemical) to the framework. The optical band gap of CP1 obtained from Tauc’s plot (2.98 eV) is comparable with the DFT computation value (HOMO and LUMO energy difference = 2.80 eV) and is crucial for the fabrication of a semiconducting device. A thin-film device ITO/ CP1 /Cu was constructed at the measured electrical conductivity of 1.57 × 10 –6 m 2 V –1 s –1 and the series resistance ( R s ) of 331 Ω, at a dark phase. Isoniazid, an antibiotic, used to prepare a Schiff base, pcih, and the present compound, CP1, motivated us to examine the anticancer efficiency against as many as four cancer cell lines (HeLa, PC3, MDA-MB 231, A549) and was compared with the NKE (human normal kidney epithelial) cell line. CP1 showed a better impact in inhibiting the proliferation of HeLa cells (IC 50: 17.58 ± 1.56 μM) than other cancer cells (IC 50: 21.52 ± 2.44 μM (PC3), 36.41 ± 1.72 μM (MDA-MB 231), 50.29 ± 3.81 μM (A549)). Loading and delivery of drug diclofenac sodium (DMNa) were tested in two different pH = 1.2 (simulated stomach environment) and pH = 7.4 (simulated intestinal environment), which showed ∼8% release at pH 1.2 and ∼87% release at pH 7.4 within 30 h. CP1, a magic material and stable in solution at different pH (1–10), showed multifaceted applications such as being energy saving, anticancer activity, and drug delivery. The design is certainly an important footstep toward the sustainable development goals (SDGs).