DataVXACS Applied Polymer MaterialsPaper
journal article·2020-10-09

Near-Infrared-Absorbing Conjugated Polymer Nanoparticles Loaded with Doxorubicin for Combinatorial Photothermal-Chemotherapy of Cancer

Wei Zhang, Yi Li, Lanju Xu, Dou Wang, Jing Long, Meng Zhang, Yufei Wang, Yuxiao Lai, Xing-Jie Liang

ACS Applied Polymer Materials· Volume 2· Issue 10
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Source abstract

Abstract

Combination therapy based on a nanoscale drug delivery system (nDDS) shows great promise in cancer therapy. We report herein the development of a nanotherapeutic that combines photothermal therapy (PTT) and chemotherapy into one nanoformula to achieve combinatorial anticancer capacity. Near-infrared (NIR)-absorbing conjugated polymers (CPs) were used as the PTT agents and coloaded with chemotherapeutic drug doxorubicin (Dox) to afford the multifunctional delivery system DCP NPs. The strong NIR absorbance of CPs endows DCP NPs with excellent photothermal capacity and NIR laser triggered drug release property. The fluorescence of Dox was quenched after encapsulation because of the fluorescence resonance energy transfer (FRET) effect between Dox and CPs, which could be used to monitor the intracellular Dox release from DCP NPs. As a result of these properties, DCP NPs exhibited very potent anticancer capacity against osteosarcoma 143B cells. This study demonstrates the great potential of CPs-based nanotherapeutic for combined photothermal-chemotherapy to combat cancer.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centre for Translational Medicine Research & Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Key Laboratory of Theoretical Organic Chemistry and Function Molecule, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China

School of Medicine, Nankai University, Tianjin 30071, China

South China National Centre of Metrology, Guangdong Institute of Metrology, Guangzhou 510405, P.R. China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

University of Chinese Academy of Sciences, Beijing 100049, P.R. China

Funding

Deutsche Forschungsgemeinschaft · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Key Laboratory of Health Informatics, Chinese Academy of Sciences · Guangdong Province · Shenzhen Fundamental Research Foundation · Bureau of Industry and Information Technology of Shenzhen

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