DataVXACS Applied Polymer MaterialsPaper
journal article·2020-02-14Open access

Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions

Jacobus A. W. Jong, Yong Guo, Cas Veenhoven, Marc-Etienne Moret, Johan van der Zwan, Alessandra Lucini Paioni, Marc Baldus, Karina C. Scheiner, Remco Dalebout, Mies J. van Steenbergen, Marianne C. Verhaar, Robert Smakman, Wim E. Hennink, Karin G. F. Gerritsen, Cornelus F. van Nostrum

ACS Applied Polymer Materials· Volume 2· Issue 2
Publisher pageOpen full text
Source abstract

Abstract

For realization of a wearable artificial kidney based on regeneration of a small volume of dialysate, efficient urea removal from dialysate is a major challenge. Here a potentially suitable polymeric sorbent based on phenylglyoxaldehyde (PGA), able to covalently bind urea under physiological conditions, is described. Sorbent beads containing PGA groups were obtained by suspension polymerization of either styrene or vinylphenylethan-1-one (VPE), followed by modification of the aromatic groups of poly(styrene) and poly(VPE) into PGA. It was found that PGA-functionalized sorbent beads had maximum urea binding capacities of 1.4-2.2 mmol/g and removed ∼0.6 mmol urea/g in 8 h at 37 °C under static conditions from urea-enriched phosphate-buffered saline, conditions representative of dialysate regeneration. This means that the daily urea production of a dialysis patient can be removed with a few hundred grams of this sorbent which, is an important step forward in the development of a wearable artificial kidney.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Covalent Organic Framework Applications · Metal-Organic Frameworks: Synthesis and Applications · Membrane Separation and Gas Transport

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands

Department of Nephrology and Hypertension, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands

Organic Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands

NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

Inorganic Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands

Innovista, Raadhuisstraat 1, 1393 NW Nigtevecht, The Netherlands

Funding

Nierstichting · H2020 European Research Council · Nederlandse Organisatie voor Wetenschappelijk Onderzoek · Sectorplan Natuur- en Scheikund

References (45)

Show source-provided references
1. 10.1093/ndt/gfx03910.1093/ndt/gfx039 ↗
2. 10.1172/jci.insight.8639710.1172/jci.insight.86397 ↗
3. 10.1111/j.1440-1797.2010.01321.x10.1111/j.1440-1797.2010.01321.x ↗
4. 10.1016/S0140-6736(07)61864-910.1016/S0140-6736(07)61864-9 ↗
5. 10.1152/ajprenal.00094.201810.1152/ajprenal.00094.2018 ↗
6. 10.1111/j.1525-1594.1981.tb04016.x10.1111/j.1525-1594.1981.tb04016.x ↗
7. 10.1080/17434440.2018.146269710.1080/17434440.2018.1462697 ↗
8. 10.1002/jbm.82017040510.1002/jbm.820170405 ↗
9. 10.1007/BF0244133110.1007/BF02441331 ↗
10. Smakman, R. Macromolecular carbonyl groups containing material suitable for use as sorbent for nitrogen compounds. U.S. Patent 4,897,200, 1990.
11. Smakman R. · Clin. Nephrol. · 1986 · 26 · S58
12. Poss, M. J.; Blom, H.; Odufu, A.; Smakman, R. Macromolecular ketoaldehydes. U.S. Patent 6,861,473 B2, 2005.
13. Kuntz, E.; Quentin, J. P. Alkenylaromatic polymers with α-ketoalhydic groups. U.S. Patent 3.933.753, 1976.
14. Kuntz, E.; Quentin, J. P. Process for extracting urea from a solution with alkenylaromatic polymers with a-ketoalhydic groups. U.S. Patent 3.933.753, 1977.
15. 10.1021/acsomega.9b0117710.1021/acsomega.9b01177 ↗
16. Frisch Micheal J. · 2009
17. Jong, G. J. D. Ion exchangers from poly(aminostyrene) and ethylene imine. U.S. Patent US3582505A, 1971.
18. 10.1016/j.tetlet.2014.01.08310.1016/j.tetlet.2014.01.083 ↗
19. 10.1021/jo061701310.1021/jo0617013 ↗
20. 10.1021/ol052517r10.1021/ol052517r ↗
21. 10.1039/C8SM00686E10.1039/C8SM00686E ↗
22. 10.1006/jmre.1999.189610.1006/jmre.1999.1896 ↗
23. 10.1515/pac-2014-111710.1515/pac-2014-1117 ↗
24. 10.1021/ja01145a12610.1021/ja01145a126 ↗
25. 10.1021/ja01236a04610.1021/ja01236a046 ↗
26. 10.1007/BF0148451310.1007/BF01484513 ↗
27. 10.1002/slct.20180004010.1002/slct.201800040 ↗
28. Clayden, J.; Warren, S.; Greeves, N.; Wothers, P. Organic Chemistry; Oxford University Press, 2000; p 561.
29. 10.1016/j.progpolymsci.2011.07.00610.1016/j.progpolymsci.2011.07.006 ↗
30. 10.1021/ma020979410.1021/ma0209794 ↗
31. 10.1021/ol027243b10.1021/ol027243b ↗
32. 10.1021/jo00225a00410.1021/jo00225a004 ↗
33. 10.1021/ja01524a08010.1021/ja01524a080 ↗
34. 10.1163/15685550778183362010.1163/156855507781833620 ↗
35. 10.1021/ma001514l10.1021/ma001514l ↗
36. 10.1002/pen.76014021110.1002/pen.760140211 ↗
37. Van Krevelen, D. M. Properties of Polymers; 1990; pp 198–203.
38. 10.1039/b003596n10.1039/b003596n ↗
39. 10.1002/app.4697910.1002/app.46979 ↗
40. 10.3390/polym1102024610.3390/polym11020246 ↗
41. Hanssen C. M. · 1967
42. 10.1016/j.polymer.2006.03.01310.1016/j.polymer.2006.03.013 ↗
43. 10.1002/app.1990.07041070610.1002/app.1990.070410706 ↗
44. 10.1039/C5RA26604A10.1039/C5RA26604A ↗
45. 10.1039/jr933000062510.1039/jr9330000625 ↗