Sr²⁺ Sustained Release System Augments Bioactivity of Polymer Scaffold

Fangwei Qi; Zhihui Wang; Yang Shuai; Shuping Peng; Cijun Shuai

doi:10.1021/acsapm.2c00024

journal article·2022-04-08

Sr²⁺ Sustained Release System Augments Bioactivity of Polymer Scaffold

Fangwei Qi, Zhihui Wang, Yang Shuai, Shuping Peng, Cijun Shuai

ACS Applied Polymer Materials· Volume 4· Issue 4

Publisher page

Source abstract

Abstract

Strontium ion (Sr2+) enabled us to endow polymer bone scaffolds with bioactivity owing to its excellent osteoinductive capacity. Nevertheless, the burst release of Sr2+ hindered its further application. Herein, strontium substituted hydroxyapatite (SrHA) was constructed to achieve a sustained release system. Specifically, Sr2+ could substitute Ca2+ in a HA lattice framework through ion exchange due to their similar ion radius. The ionic bond formed by Sr2+ and surrounding ions could prevent the rapid escape of Sr2+ and thereby achieve the sustained release of Sr2+. Subsequently, SrHA was introduced into the poly-l-lactic (PLLA) scaffold fabricated by selective laser sintering. Results demonstrated that PLLA/SrHA scaffolds presented a sustained Sr2+ release with a cumulative concentration of 5.6 mg/L over 28 days. The released Sr2+ significantly promoted the cell proliferation and differentiation. Furthermore, the tensile and compressive strengths of PLLA/SrHA scaffolds were also greatly enhanced in comparison with that of PLLA scaffolds. These positive findings demonstrated that PLLA/SrHA scaffolds had considerable potential for bone repair.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Ceramics & glasses

OpenAlex topics: Bone Tissue Engineering Materials · Additive Manufacturing and 3D Printing Technologies · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China

State Key Lab of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, Central South University, Changsha, Hunan 410078, China

NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Cancer Research Institute, Central South University, Changsha, Hunan 410013, China

State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China

Funding

State Key Laboratory of Polymer Materials Engineering · State Key Laboratory of High Performance Complex Manufacturing · Education Department of Jiangxi Province · China Postdoctoral Science Foundation · Key Research and Development Program of Jiangxi Province · National Natural Science Foundation of China · Natural Science Foundation of Jiangxi Province

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