A computationally guided study of a blood heat exchanger and the construction of an extracorporeal circulation system for selective brain cooling
Source abstract
Abstract
Achieving long-lasting hypothermia neuroprotection against reperfusion injury in patients with acute ischemic stroke (AIS) by using intra-arterial selective cooling infusion with autologous blood (IA-SCAI) is promising. However, due to the lack of a specialized medical circulatory perfusion system matching cerebral blood flow characteristics, we conduct a translational study of an extracorporeal circulation system for continuous and controllable brain cooling using an optimized blood heat exchanger (BHE). In contrast to commercial BHEs, optimized BHEs are prone to reducing thrombogenic risk potential under a low infusion rate (10–50 mL/min) in IA-SCAI. The designed BHE provided effective cerebral cooling (∼2°C) for 22 min during a 30-min cooling period in a swine model. These results suggest that the selective brain cooling induced by cold autologous blood perfusion was safe, which could promote the clinical application of an autologous extracorporeal circulation system for AIS therapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Thermal Regulation in Medicine · Cardiac Ischemia and Reperfusion · Cardiac Arrest and Resuscitation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (46)
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