journal article·2019-06-14

Scalable Aqueous Reversible Addition–Fragmentation Chain Transfer Photopolymerization-Induced Self-Assembly of Acrylamides for Direct Synthesis of Polymer Nanoparticles for Potential Drug Delivery Applications

Neomy Zaquen, Huijie Zu, Ak M.N.B.P.H.A. Kadir, Tanja Junkers, Per B. Zetterlund, Cyrille Boyer

ACS Applied Polymer Materials· Volume 1· Issue 6
Publisher page

Abstract

The synthesis of polymer nanoparticles for potential drug delivery applications via photoinduced electron transfer–reversible addition–fragmentation chain transfer aqueous dispersion polymerizations employing Eosin Y/triethanol amine as catalytic system is described. A scalable synthesis procedure for the polymerization of poly(dimethyl acrylamide)-b-(poly(diaceteone-stat-dimethyl acrylamide)) is reported under visible light (λmax = 530 nm). A variety of solid contents and block lengths for the solvophilic and solvophobic blocks are investigated, expanding the compositional space of worms, jellyfish, and vesicles using flow chemistry. A simple two-step process using a coupled flow reactor setup is used without the need for intermediate purification.
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Research context

OpenAlex topics: Advanced Polymer Synthesis and Characterization · Innovative Microfluidic and Catalytic Techniques Innovation · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, The University of New South Wales, High Street Gate 2, 2033 Kensington, Sydney, Australia

Australian Centre for Nanomedicine, School of Chemical Engineering, The University of New South Wales, High Street Gate 2, 2033 Kensington, Sydney, Australia

Organic and Bio-Polymer Chemistry (OBPC), Universiteit Hasselt, Agoralaan Building D, 3590 Diepenbeek, Belgium

Polymer Reaction Design Group, School of Chemistry, Monash University, 19 Rainforest Walk, Melbourne, Victoria 3800, Australia

Funding

H2020 Marie Sklodowska-Curie Actions · Fonds Wetenschappelijk Onderzoek

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