DataVXACS Applied Polymer MaterialsPaper
journal article·2023-08-11Open access

Photocrosslinked Gelatin Methacryloyl (GelMA)/Hyaluronic Acid Methacryloyl (HAMA) Composite Scaffold Using Anthocyanidin as a Photoinitiator for Bone Tissue Regeneration

Yu-Chien Lin, Evangeline Jafneel Nixon, Huey-Yuan Wang, Udesh Dhawan, Yu-Wen Huang, Shih-Hao Huang, Cho-Pei Jiang, Yi-Jie Kuo, Ren-Jei Chung

ACS Applied Polymer Materials· Volume 5· Issue 8
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Source abstract

Abstract

Gelatin and hyaluronic acid are natural biopolymers that are important components of soft tissues in the human body, and both have been used in several biomedical applications. To achieve controllable mechanical and degradation properties of gelatin and hyaluronic acid, methacrylic acid has been used to modify photocrosslinkable gelatin methacryloyl (GelMA) and hyaluronic acid methacryloyl (HAMA). Irgacure 2959 (I2959) and anthocyanidin have been used as photoinitiators for comparison. Finally, the photocrosslinked GelMA/HAMA composite scaffold has been prepared for bone tissue regeneration. The composite scaffolds were prepared using mold casting and photocrosslinking techniques. Specific ratios of GelMA and HAMA reagents were mixed properly with I2959 or anthocyanidin photoinitiators. Samples were examined with chemical and material, in vitro, and in vivo evaluations. Furthermore, two photoinitiators, I2959 and anthocyanidin, can crosslink the GelMA/HAMA composite scaffold. A 1% HAMA incorporation can significantly decrease the degradation of the GelMA/HAMA scaffold compared with GelMA only. Also, HAMA participation can improve cell viability and promote bone-related cell differentiation and tissue regeneration (bone formation) without any apparent adverse reactions in vivo .
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Research context

Composites

OpenAlex topics: Photopolymerization techniques and applications · Bone Tissue Engineering Materials · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 106344, Taiwan

Department of Stomatology, MacKay Memorial Hospital, Taipei 104217, Taiwan

Centre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glasgow G116EW, United Kingdom

Institute of Manufacturing Technology, National Taipei University of Technology (Taipei Tech), Taipei 106344, Taiwan

Department of Mechanical Engineering, National Taipei University of Technology (Taipei Tech), Taipei 106344, Taiwan

Department of Intelligent Automation Engineering, National Taipei University of Technology (Taipei Tech), Taipei 106344, Taiwan

Department of Orthopedic Surgery, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan

Department of Orthopedic Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan

Funding

National Taipei University of Technology · Ministry of Science and Technology, Taiwan · Mackay Memorial Hospital

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