Hydrophilic Polymer-Grafted Nanodiamonds as Nonmetallic Magnetic Resonance Imaging Contrast Agents
Source abstract
Abstract
Nanodiamonds (NDs) have gained increasing attention in biomedical applications and theranostics owing to their exceptional physicochemical stability, biocompatibility, nontoxicity, intrinsic optical and magnetic properties, and highly adaptable surface functionalization capabilities. This study aims to generate weak surface ferromagnetism in NDs by thermally oxidizing them in air at 550 °C. Following oxidation, the NDs were grafted with hydrophilic, biocompatible ligands including dextrose, polyethylene glycol diacid, polyethylene imine, and poly(acrylic acid) to enhance their colloidal stability and biocompatibility. Through a comprehensive analysis of water proton spin relaxivities and in vivo T 1 and/or T 2 magnetic resonance (MR) images acquired at 3 T, this study demonstrated the potential of hydrophilic, biocompatible ligand-grafted NDs to serve as a new class of nonmetallic T 1 and/or T 2 MR imaging contrast agents.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Diamond and Carbon-based Materials Research · Nanoparticle-Based Drug Delivery · Chemotherapy-induced cardiotoxicity and mitigation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, College of Natural Sciences
Kyungpook National University
Division of RI-Convergence Research
Korea Institute of Radiological and Medical Science
Institute of Biomedical Engineering Research, School of Medicine
Division of Biomedical Science, School of Medicine
Department of Biology Education, Teachers’ College
Department of Chemistry Education, Teachers’ College
Department of Molecular Medicine, School of Medicine
Funding
National Research Foundation of Korea
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