Review of Stimuli-Responsive Polymeric Prodrug Nanomaterials for Cancer Therapy
Source abstract
Abstract
Off-target effects of conventional chemotherapeutics often cause severe toxicities, posing a persistent clinical obstacle in cancer therapy. Nanodelivery systems can enhance tumor accumulation via the enhanced permeability and retention effect, yet reconciling systemic stability with rapid and site-specific drug release remains a longstanding challenge. Stimuli-responsive polymeric prodrugs, which integrate tumor microenvironment-responsive linkages with polymer-drug conjugation strategies, offer a promising solution by combining improved circulatory stability with selective activation at tumor sites. In this review, we summarize recent advances in the design of stimuli-responsive polymeric prodrugs according to characteristic tumor microenvironmental features, discuss their representative applications and mechanistic advantages, and outline the current limitations, translational challenges, and future directions in this field.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals
Zhejiang University of Technology
College of Biotechnology and Bioengineering
Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs
Funding
National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs
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