DataVXACS Applied Nano MaterialsPaper
journal article·2026-04-10

Synergistic Sono-Gene Therapy of Gastric Cancer via Nanoparticle-Based Delivery of Chlorin e6 and siRNA

Tingting Xiang, Ying Xia, Hong Du, Yong Jin, Dicheng Yang, Depeng Liu, Sixi Wei, Cunfeng Song, Hai Huang

ACS Applied Nano Materials· Volume 9· Issue 14
Publisher page
Source abstract

Abstract

Gastric cancer remains one of the most pressing global health challenges, with its high mortality rate primarily attributed to aggressive tumor invasiveness and strong metastatic potential. This grim scenario underscores the urgent need for effective, feasible, and innovative therapeutic strategies. In this study, we developed a targeted nanoparticle system (iBCsi) that codelivers the sonosensitizer chlorin e6 (Ce6) and small interfering RNA (siRNA) for sono-gene therapy. It has a size of 100.21 ± 1.22 nm. This system enables the implementation of a “suppress EMT-promote apoptosis” strategy: Specifically, the siRNA reduces tumor invasiveness via downregulating LINC00963, an overexpressed long noncoding RNA (LncRNA) known to drive epithelial–mesenchymal transition (EMT). Concurrently, upon ultrasound irradiation, iBCsi generates high levels of reactive oxygen species (ROS), thereby inducing tumor cell apoptosis. This synergistic therapeutic approach successfully suppresses tumor growth and EMT via the combination of gene silencing and sonodynamic therapy, not only deepening the mechanistic understanding of gastric cancer therapy but also enhancing its translational potential within precision oncology.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Ultrasound and Hyperthermia Applications · Nanoplatforms for cancer theranostics · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Clinical Laboratories

The Affiliated Hospital of Guizhou Medical University

Department of Clinical Laboratory

Jinshan Branch of Shanghai Sixth People’s Hospital

The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine

Division of Gastroenterology and Hepatology, Department of Medicine and Department of Oncology, Sidney Kimmel Comprehensive Cancer Center

Johns Hopkins University School of Medicine

Clinical Laboratory of the Second People’s Hospital of Guizhou Province

National Engineering Research Center for Nanotechnology

Department of Radiology

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

School of Clinical Laboratory Science

Guizhou Medical University

School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering

Shanghai Jiao Tong University

Faculty of Chemical Engineering and Energy Technology

Shanghai Institute of Technology

School of Laboratory Medicine

Zunyi Medical University

Department of Laboratory Medicine

Affiliated Hospital of Zunyi Medical University

Funding

Guizhou Medical University · Guizhou Provincial Science and Technology Department · National Natural Science Foundation of China · Key Laboratory for Cancer Prevention and treatment of Guizhou Province · Guizhou Provincial Basic Research Program (Natural Science)

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