DataVXACS Applied Nano MaterialsPaper
journal article·2025-12-26

Covalent Organic Framework Biomaterial Enhances Osteogenesis via Wnt/β-Catenin Pathway Activation

Feifei Pu, Yaoyao Bai, Linwei He, Long Chen, Zhe Wang, Yihan Yu, Mengxue Liang, Shiyu Hou, Yuting Gao, Fengxia Chen

ACS Applied Nano Materials· Volume 8· Issue 51
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Source abstract

Abstract

Bone defects caused by trauma, tumors, and degenerative diseases remain a major clinical challenge, necessitating effective strategies for bone repair. Traditional bone grafting approaches are limited by issues such as donor scarcity and immune rejection, highlighting the need for alternative strategies. Stem cell-based regenerative therapies, particularly those utilizing bone marrow mesenchymal stem cells (BMSCs), offer promising solutions due to their osteogenic potential. Herein, we report the synthesis of a porous and biocompatible nanostructured COF-Imine material and systematically evaluate its ability to promote BMSC osteogenic differentiation for bone regeneration. Our findings demonstrate that COF-Imine significantly enhances osteogenesis by activating the Wnt/β-catenin signaling pathway through multiple mechanisms, which facilitates the expression of key osteogenic genes such as ALP, OCN, COL1, and Runx2. In vivo experiments using a rat calvarial defect model further confirm that COF-Imine accelerates bone defect repair, underscoring its potential as a biomaterial for bone tissue engineering applications.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Covalent Organic Framework Applications · Nanoplatforms for cancer theranostics · Mesenchymal stem cell research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedics, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College

Huazhong University of Science and Technology

Department of Orthopaedics

Wuhan No.1 Hospital

State Key Laboratory of Radiation Medicine and Protection, School of Radiological and Interdisciplinary Sciences (RAD-X)

Soochow University

Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions

Department of Orthopaedics, Union Hospital, Tongji Medical College

Engineering Research Center of Nano-Geomaterials of the Ministry of Education, Faculty of Materials Science and Chemistry

China University of Geosciences

Department of Radiation and Medical Oncology

Zhongnan Hospital of Wuhan University

Funding

National Key Research and Development Program of China · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Postdoctoral Innovation Practice Post in Hubei Province

References (21)

Show source-provided references
1. 10.1097/BOT.000000000000111510.1097/BOT.0000000000001115 ↗
2. 10.1111/jcpe.1305810.1111/jcpe.13058 ↗
3. 10.1016/j.bone.2015.07.00710.1016/j.bone.2015.07.007 ↗
4. 10.3171/2016.1.SPINE15100510.3171/2016.1.SPINE151005 ↗
5. 10.1016/j.jpor.2017.08.01010.1016/j.jpor.2017.08.010 ↗
6. 10.1016/j.stem.2019.05.00510.1016/j.stem.2019.05.005 ↗
7. 10.3390/ijms2124975910.3390/ijms21249759 ↗
8. 10.3390/cells808078410.3390/cells8080784 ↗
9. 10.2147/IJN.S21388910.2147/IJN.S213889 ↗
10. 10.1002/adhm.20200136910.1002/adhm.202001369 ↗
11. 10.1039/D0NR06297A10.1039/D0NR06297A ↗
12. 10.1002/adhm.20200209010.1002/adhm.202002090 ↗
13. 10.1016/j.redox.2024.10310610.1016/j.redox.2024.103106 ↗
14. 10.1038/s41467-024-54227-910.1038/s41467-024-54227-9 ↗
15. 10.1002/chem.20190515010.1002/chem.201905150 ↗
16. 10.3390/nano801001510.3390/nano8010015 ↗
17. 10.1021/acsami.8b0548410.1021/acsami.8b05484 ↗
18. 10.1039/C9SC00172G10.1039/C9SC00172G ↗
19. 10.1038/nbt.333010.1038/nbt.3330 ↗
20. 10.1016/j.tice.2017.12.00510.1016/j.tice.2017.12.005 ↗
21. 10.1080/09205063.2019.164662810.1080/09205063.2019.1646628 ↗