Manganese–Cerium Bimetallic Organic Framework Nanozyme as an Antioxidant for Scavenging Vapor-Phase Reactive Oxygen Species in Cigarette Smoke

Pulmonary diseases caused by cigarette smoke have become a major global health concern, with reactive oxygen species (ROS) in smoke playing a key role in inducing oxidative damage. However, conventional cigarette filters have limited effectiveness in eliminating these harmful radicals. This study presents a promising strategy using a manganese–cerium bimetallic organic framework (Mn/Ce-MOF) as a smoke radical scavenger. Mn/Ce-MOFs show significant free radical scavenging capabilities, including superoxide dismutase (SOD)-like activity, catalase (CAT)-like activity, and hydroxyl radical (·OH) neutralization. When incorporated into cigarette filters, Mn/Ce-MOFs achieve over 72.5% scavenging efficiency for ROS present in cigarette smoke. In vivo experiments demonstrate that cigarettes modified with Mn/Ce-MOF nanozymes reduce lung inflammation caused by oxidative stress, offering significant protection to lung tissue. This work highlights the potential of Mn/Ce-MOFs as powerful antioxidant additives in cigarette filters, representing a promising approach to mitigate the harmful effects of smoking.