Imitating Substrate Channels on a Mesoporous SiO2-Confined Fe1 Single-Atom Nanozyme for Enhancing Peroxidase-like Activity
Source abstract
Abstract
Single-atom nanozymes (SAzymes) are an emerging class of artificial enzymes that integrate metal single atoms on nanostructured supports, combining high catalytic efficiency with enzyme-like functionality. However, most designs have overlooked the role of substrate channels, which are essential in natural enzymes for enhancing specificity, accelerating kinetics, and suppressing side reactions. Herein, we design a bioinspired Fe 1 @ SAzyme by confining Fe 1 single atoms within mesoporous SiO 2 (m-SiO 2 ) to imitate the function of enzymatic substrate channels. The periodic mesopores of m-SiO 2 not only ensure uniform Fe 1 dispersion but also enhance substrate transport and shorten radical migration pathways, thereby significantly boosting the peroxidase-like activity to conventional Fe-based nanozymes. This work bridges heterogeneous and enzyme catalysis, offering a promising strategy for next-generation nanozyme development.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Interdisciplinary Research Center of Biology & Catalysis, School of Life Sciences
Northwestern Polytechnical University
Research & Development Institute of Northwestern Polytechnical University in Shenzhen
School of Materials Science and Engineering
Xi’an University of Technology
School of Chemical and Environmental Engineering
Shanghai Institute of Technology
Analytical & Testing Center
Chongqing Innovation Center
State Key Laboratory of Coal Conversion
Institute of Coal Chemistry, Chinese Academy of Sciences
Funding
Natural Science Foundation of Chongqing Municipality · Basic and Applied Basic Research Foundation of Guangdong Province · National Natural Science Foundation of China · Foundation of State Key Laboratory of Coal Conversion
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