A High Anti-interference Trimode Hydrogen Peroxide Sensing Strategy via Inner Filter Effect between the Anthracene-Based Probes and NaYF₄:Yb/Tm/Er Nano Hexagonal Prisms

The exploration of efficient hazardous chemical sensing technology is of great importance to protect the environment and maintain public security. Here, a design strategy of a trimode upconversion nanoprobe was developed for H 2 O 2 detection through establishing the inner filter effect (IFE) between the anthracene-based probes and the NaYF 4:Yb/Tm/Er upconversion nanoparticles (UCNPs). The trimode nanoprobe exhibits superior H 2 O 2 detection performance, including a low limit of detection (LOD) of 152 nM, fast response (<3 s), outstanding selectivity, and robust anti-interference ability even in the presence of 15 common interferents. Furthermore, the practical utility of this design is conclusively demonstrated through a sensing chip capable of accurately and selectively identifying H 2 O 2 even in the presence of more than 7 types of coexisting multicolor interferents. This sensing strategy, characterized by its strong anti-interference capability even when facing extremely complex real-world samples, is expected to establish a promising framework for ultra-accurate detection of hazardous substances.