DataVXACS Applied Nano MaterialsPaper
journal article·2023-07-28

RHCG-Upregulating Polymeric Nanoparticles for Sensitized Chemotherapy and Immunotherapy in Head and Neck Squamous Cell Carcinoma

Huihui Zou, Zheng Wei, Wenguang Xu, Xinyu Zhang, Jianchuan Ran, Guorong Zhang, Zichen Cao, Tao Liu, Meng Zhou, Wei Han

ACS Applied Nano Materials· Volume 6· Issue 14
Publisher page
Source abstract

Abstract

Immunotherapy and multifactor-induced chemoresistance for HNSCC are accompanied by a high incidence of adverse side effects. In clinics, it is urgently required to alleviate adverse effects and improve chemosensitivity. The drug delivery system (named TP NPs) based on poly (I:C) was synthesized using poly(ethylene glycol) (PEG) diamine as the shell. The NPs triggered in situ antitumor immune response and effectively enhanced the sensitivity of cancer cells to cisplatin. Meanwhile, TP NPs proved a slow release rate of PIC, and PIC binds to the TLR3 receptor in the cytoplasm, upregulating the tumor suppressor gene RHCG. Furthermore, TP NPs accumulated at the tumor site and triggered antitumor immune activation, including promoting DC maturation and shifting macrophages into M1 macrophages in a xenograft mouse tumor model. TP NPs effectively destroyed the tumors via combinatorial therapy in vitro and in vivo, providing a strategy for head and neck squamous cell carcinoma.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Immunotherapy and Immune Responses · RNA Interference and Gene Delivery · Immune cells in cancer

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008 Nanjing, China

Jiangbei Medical Center, Nanjing Stomatological Hospital, Medical School of Nanjing University, NO 359 Puzhu Middle Road, Jiangbei new district, 210008 Nanjing, china

Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008 Nanjing, China

Nanjing Stomatology Hospital, Medical School of Nanjing University, Pediatric Dentistry, No 30 Zhongyang Road, Nanjing 210008, China

Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing 210008, China

Department of Oral and Maxillofacial Surgery, Xuzhou Stomatological Hospital, The Affiliated Stomatological Hospital of Xuzhou Medical University, No,130 Huaihai West Road, 221004 Xuzhou, China

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Nanjing Municipal Health Bureau

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