Modulation of Macrophage Polarization via Fluorescein Conjugation with Iron Oxide Nanoparticles for MR Imaging
Source abstract
Abstract
We reported the regulation of macrophage polarization by iron oxide nanoparticles through conjugation with fluorescein and polyethylene glycol. When the modified nanoparticles were taken up by macrophages, the M2 phenotype was induced by upregulating anti-inflammatory markers such as CD163 and CD209, as well as associated transcripts such as IL10 and TGF-β, potentially for use as an MR contrast agent with minimal pro-inflammatory stimulation.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Supramolecular Self-Assembly in Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Cerebral and Cardiovascular Center Research Institute, Kishibe Shimmachi, Suita, Osaka 564-8565, Japan
Funding
Japan Society for the Promotion of Science
References (23)
Show source-provided references
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