Detoxification of Chemical Warfare Agents at Physiological pH Using UiO-66(Zr)/Gelatin Hydrogel Composite
Source abstract
Abstract
Zirconium-based metal–organic frameworks (MOFs) are increasingly recognized as promising materials for decontaminating organophosphate (OP) chemical warfare agents (CWAs), thanks to their high Lewis and Bro̷nsted acidity, notable stability, and permanent porosity. However, their practical use is limited by challenges related to the required highly alkaline media to perform efficient decontamination, while at neutral pH, conversion of CWAs into nontoxic end products is mostly insignificant. There is a significant lack of research conducted under physiological conditions, and existing studies are primarily focused on a limited number of CWAs. In this work, we not only have exploited a Zr-based MOF UiO-66(Zr) to study the hydrolysis of a series of CWAs at physiological pH, but also explored its hydrogel composite with gelatin to show significant improvement in the kinetics of the hydrolysis of a series of OP CWAs and pesticides to obtain conversion as high as 100% with a promising half-life of lower than 5 min. The recycling ability of the MOF and the MOF/gelatin composite was exploited to show minimal loss of activity over three consecutive cycles.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Sulfur Compounds in Biology · Biochemical effects in animals · Metal-Organic Frameworks: Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratoire de Chimie Bioorganique et Bioinorganique, Institut de Chimie Moléculaire et des Matériaux d’Orsay, UMR 8182, Bâtiment 670, Université Paris-Saclay, 17 Avenue des Sciences, 91400 Orsay, France
Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 1 Place du Général Valérie André, 91220 Brétigny-sur-Orge, France
Laboratoire COBRA UMR CNRS 6014, Bâtiment IRCOF - 1 Rue Tesniere, Cedex 76821 Mont-Saint-Aignan, France
Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS
Université Paris-Sud, Université Paris-Saclay
Laboratoire de Synthèse et Réactivité de Molécules pour le Vivant, Institut de Chimie Moléculaire et des Matériaux d’Orsay, UMR 8182, Bâtiment 670, Université Paris-Saclay, 17 Avenue des Sciences, 91400 Orsay, France
Institut Lavoisier de Versailles, CNRS UMR 8180
UVSQ Université Paris-Saclay
Funding
Agence Nationale de la Recherche
References (70)
Show source-provided references
1. Marrs T. T. · 200710.1002/9780470060032 ↗
2. 10.1039/C9OB00802K10.1039/C9OB00802K ↗
3. 10.2174/13852720777994089210.2174/138527207779940892 ↗
4. 10.1021/ar200286410.1021/ar2002864 ↗
5. 10.1016/j.bja.2019.04.06110.1016/j.bja.2019.04.061 ↗
6. 10.1016/j.cbi.2013.06.01210.1016/j.cbi.2013.06.012 ↗
7. 10.1016/j.toxlet.2011.05.104110.1016/j.toxlet.2011.05.1041 ↗
8. 10.1038/s41598-017-15209-810.1038/s41598-017-15209-8 ↗
9. 10.3389/fbioe.2019.0028910.3389/fbioe.2019.00289 ↗
10. 10.1080/10590501.2019.165480910.1080/10590501.2019.1654809 ↗
11. 10.1021/acscentsci.1c0093110.1021/acscentsci.1c00931 ↗
12. 10.1016/j.chemosphere.2023.14059710.1016/j.chemosphere.2023.140597 ↗
13. 10.1016/j.cej.2022.13508710.1016/j.cej.2022.135087 ↗
14. 10.1016/j.chemosphere.2009.04.05510.1016/j.chemosphere.2009.04.055 ↗
15. 10.1016/S1002-0721(14)60079-X10.1016/S1002-0721(14)60079-X ↗
16. 10.1002/cbic.20240013710.1002/cbic.202400137 ↗
17. 10.1007/s13762-022-04410-610.1007/s13762-022-04410-6 ↗
18. 10.1016/j.molliq.2023.12220610.1016/j.molliq.2023.122206 ↗
19. 10.1021/acs.jpcc.8b0364110.1021/acs.jpcc.8b03641 ↗
20. 10.1126/science.123044410.1126/science.1230444 ↗
21. Yaghi O. M. · 201910.1002/9783527821099 ↗
22. 10.1039/C4CS90059F10.1039/C4CS90059F ↗
23. 10.1002/anie.20181132710.1002/anie.201811327 ↗
24. 10.1021/acsami.2c1768210.1021/acsami.2c17682 ↗
25. 10.1021/acs.chemmater.1c0103410.1021/acs.chemmater.1c01034 ↗
26. 10.1021/ic035452210.1021/ic0354522 ↗
27. 10.1002/biot.20060016610.1002/biot.200600166 ↗
28. 10.1039/D2TA02074B10.1039/D2TA02074B ↗
29. 10.1021/acs.inorgchem.5b0181310.1021/acs.inorgchem.5b01813 ↗
30. 10.1021/acs.inorgchem.1c0222410.1021/acs.inorgchem.1c02224 ↗
31. 10.1021/acsami.9b2015410.1021/acsami.9b20154 ↗
32. 10.1016/j.xcrp.2021.10061210.1016/j.xcrp.2021.100612 ↗
33. 10.1021/acsami.2c0602510.1021/acsami.2c06025 ↗
34. 10.1038/nmat423810.1038/nmat4238 ↗
35. 10.1016/j.apcatb.2019.01.03310.1016/j.apcatb.2019.01.033 ↗
36. 10.1039/C4SC03613A10.1039/C4SC03613A ↗
37. 10.1021/acs.inorgchem.7b0180910.1021/acs.inorgchem.7b01809 ↗
38. 10.1021/acs.inorgchem.8b0236010.1021/acs.inorgchem.8b02360 ↗
39. 10.1016/j.ccr.2023.21530110.1016/j.ccr.2023.215301 ↗
40. 10.1016/j.toxlet.2020.11.00410.1016/j.toxlet.2020.11.004 ↗
41. 10.1002/cnma.20240013210.1002/cnma.202400132 ↗
42. 10.1021/acs.chemmater.6b0511510.1021/acs.chemmater.6b05115 ↗
43. 10.1021/acs.chemmater.2c0270410.1021/acs.chemmater.2c02704 ↗
44. 10.1142/S225123732240004410.1142/S2251237322400044 ↗
45. 10.1021/acs.langmuir.7b0291610.1021/acs.langmuir.7b02916 ↗
46. 10.1002/asia.20240034410.1002/asia.202400344 ↗
47. 10.1021/acsami.2c1633610.1021/acsami.2c16336 ↗
48. 10.1002/slct.20170309310.1002/slct.201703093 ↗
49. 10.1016/j.carbpol.2023.12148910.1016/j.carbpol.2023.121489 ↗
50. 10.1021/acsami.2c1869110.1021/acsami.2c18691 ↗
51. 10.1021/acsami.2c0332510.1021/acsami.2c03325 ↗
52. 10.3390/gels910081510.3390/gels9100815 ↗
53. 10.1002/adma.20230095110.1002/adma.202300951 ↗
54. 10.1021/acsami.7b0162110.1021/acsami.7b01621 ↗
55. 10.1021/acsami.7b0920910.1021/acsami.7b09209 ↗
56. 10.1021/acsami.0c0827610.1021/acsami.0c08276 ↗
57. 10.1021/acsami.8b0816710.1021/acsami.8b08167 ↗
58. 10.1021/acsami.7b1539710.1021/acsami.7b15397 ↗
59. 10.1016/j.carbpol.2019.02.04410.1016/j.carbpol.2019.02.044 ↗
60. 10.1002/anie.20160665610.1002/anie.201606656 ↗
61. 10.1002/marc.20190033310.1002/marc.201900333 ↗
62. 10.1021/acs.chemrev.9b0057510.1021/acs.chemrev.9b00575 ↗
63. 10.1021/cm202640w10.1021/cm202640w ↗
64. Steunou N. · 2016 · 27510.1002/9781119242604.ch8 ↗
65. 10.1039/C5TA10401G10.1039/C5TA10401G ↗
66. 10.1039/D3SC03659F10.1039/D3SC03659F ↗
67. 10.1021/acs.cgd.5b0119010.1021/acs.cgd.5b01190 ↗
68. 10.1179/01971360780611233210.1179/019713607806112332 ↗
69. 10.1016/j.checat.2021.06.00810.1016/j.checat.2021.06.008 ↗
70. 10.1021/acsami.1c0813810.1021/acsami.1c08138 ↗