DataVXACS Applied Nano MaterialsPaper
journal article·2025-02-07Open access

Testicular Toxicity Assessment of Chronic Low-Dose Exposure to Polystyrene Nanoparticles in Multiexposure Models Using Drosophila

Qiuru Huang, Qiushi Xia, Yujuan Qi, Cong Shen, Jiaxin Li, Ziyue Pan, Yiheng Liu, Yi Zhang, Qingqing Hu, Pengfei Huan, Chenyu Wang, Xinda Wang, Chen Qiao, Bo Zheng, Xinyuan Zhao, Zhonghua Shi, Jun Yu, Xiaoqing Yang

ACS Applied Nano Materials· Volume 8· Issue 5
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Abstract

High Resolution Image Download MS PowerPoint Slide Recent research has underscored the widespread presence of plastic in diverse ecosystems, prompting concerns about its potential long-term impacts on organisms. However, the reproductive toxicity of polystyrene nanoparticles (PSNPs) is contingent on factors, such as drug concentrations, exposure duration, delivery method, and PSNP characteristics. Consequently, the evaluation of testicular toxicity stemming from chronic PSNP exposure warrants a systematic investigation. This study extensively probed the potential toxicity of PSNPs on testes using multiexposure models. Three distinct long-term exposure paradigms (adult, gestational, and cross-generational exposure) were executed to assess PSNP-induced testicular toxicity (80 nm) in Drosophila . Nevertheless, spermatogenesis exhibited no discernible alterations following exposure to 75, 150, and 300 μg/mL of PSNPs in the adult and gestational exposure models. Furthermore, cross-generational exposure to PSNPs did not perturb testicular phenotype or offspring fertility from the F1 to F4 generations. These findings imply that chronic consumption of low-dose PSNPs may not suffice to induce testicular dysfunction, providing fresh insights into the dosage and duration of PSNP exposure.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Microplastics and Plastic Pollution · Nanoparticles: synthesis and applications · Effects and risks of endocrine disrupting chemicals

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Obstetrics and Gynecology, The Affiliated Hospital of Nantong University

Nantong University

Institute of Reproductive Medicine, School of Medicine

Clinical Center of Reproductive Medicine, Xuzhou Central Hospital

Xuzhou Clinical School of Xuzhou Medical University

State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School

Nanjing Medical University

Department of Urology, Xuzhou Central Hospital

Department of Clinical Pharmacy, The Affiliated Hospital of Jiangsu University

Jiangsu University

Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health

Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Changzhou Key Laboratory of Maternal and Child Health Medicine

Funding

Qinglan Project of Jiangsu Province of China · China Postdoctoral Science Foundation · Natural Science Foundation of Jiangsu Province · Xuzhou Municipal Science and Technology Bureau · National Natural Science Foundation of China · Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University · Suzhou Gu Su Health Talent Research Project · Gusu School, Nanjing Medical University

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