journal article·2024-12-13

Light-Activated Silver Ion Release from Ag2Te Nanoparticles for Treating Drug-Resistant Bacterial Keratitis

Jingke Yao, Xunjie Shang, Jiayi Wei, Liting Guo, Feifan Sheng, Nannan Shao, Limin Chen, Zhe Zhang, Yunlong Zhou, Wei Chen

ACS Applied Nano Materials· Volume 7· Issue 23
Publisher page

Abstract

Biofilm and multidrug-resistant bacteria limit therapy effects on bacteria keratitis. Hence, we developed an all-in-one strategy based on a photothermal trigger to combat multidrug-resistant bacteria and eradicate biofilm. In the nanoplatforms, BSA-Ag 2 Te nanoparticles (NPs) fabricated by a one-step synthesis approach were utilized as photothermal agents to generate low temperature (40–48 °C) and then modified with RGD (Arg-Gly-Asp) to increase the drug concentration and retention in the cornea. The heat generated from photothermal therapy can accelerate the Ag + release. In addition, laser-triggered release of Ag + can significantly increase the ROS content in the bacteria. This synergistic approach could effectively eradicate multidrug-resistant bacteria and biofilm by photothermal therapy (PPT) and the combination of Ag + and ROS. Based on the synergistic treatment of PTT, Ag +, and ROS, BSA-Ag 2 Te@RGD NPs exhibited outstanding antibacterial effects on a mice MRSA-infected keratitis model. BSA-Ag 2 Te@RGD NPs will be promising candidates for applications of low-temperature PTT in bacterial keratitis treatments.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Retinal and Optic Conditions · Ocular Infections and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Ningbo Eye Institute, Ningbo Eye Hospital, Wenzhou Medical University, Ningbo 315040, China

National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China

National Clinical Research Center for Ocular Diseases Eye Hospital Wenzhou Medical University, Wenzhou 325027, China

Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China

Department of Chemical and Pharmaceutical Engineering, Hefei Normal University, Hefei, Anhui 230601, China

CAS Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China

Deep-Processing of Fine Flake Graphite Sichuan Province Key Laboratory of Colleges and Universities, Panzhihua University, No. 10, Jichang Road, Panzhihua, Sichuan 617000, China

Funding

Science and Technology Department of Zhejiang Province · National Natural Science Foundation of China · Ningbo Eye Hospital · Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province · Major Science and Technology Project of Wenzhou Science and Technology

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