DataVXACS Applied Nano MaterialsPaper
journal article·2025-02-21

Electric Field Modulation on MoS2 Nanoreactors for Enhanced Photodynamic Therapy of Severe Acute Pancreatitis

Ruixi Chu, Yuansong Sun, Jianhua Liu, Yibin Du, Weihong Chen, Rongrong Gu, Sheng Ye

ACS Applied Nano Materials· Volume 8· Issue 7
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Source abstract

Abstract

Severe acute pancreatitis (SAP) is one of the most common gastrointestinal emergencies in clinical practice. However, there are many limitations in clinical treatment, such as complicated processes with a long cycle and poor prognosis. As one of the emerging therapeutic methods in recent years, nanomaterial-mediated photodynamic therapy (PDT) has brought light to the treatment of disease. In this work, we design three morphologically controlled MoS 2 nanoreactors for SAP photodynamic therapy. The hollow MoS 2 (H-MoS 2 ) nanoreactor possesses the highest electric field intensity and light absorption, resulting in the best therapeutic effects under 808 nm of irradiation. The amylase and lipase were reduced to one-third of the SAP, and the apoptosis rate of pancreatic acinar cells was reduced to one-half of that in the SAP. Our work opens a window for the construction of high-performance nanomedicine for SAP photodynamic therapy, especially in more inflammatory diseases.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Pancreatitis Pathology and Treatment · Phagocytosis and Immune Regulation · COVID-19 Clinical Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Agricultural Photocatalysis Laboratory, School of Materials and Chemistry & College of Veterinary Medicine

Anhui Agricultural University

Department of Emergency Surgery & Research Center of Minimally Invasive Intervention

The Second Affiliated Hospital of Anhui Medical University

Department of Critical Care Medicine

The Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou)

Department of Spinal Orthopaedics

The Third Affiliated Hospital of Anhui Medical University (The First People’s Hospital of Hefei)

Funding

Science Fund for Distinguished Young Scholars of Anhui Province · Anhui Agricultural University · Anhui Medical University · National Natural Science Foundation of China · Anhui Provincial Health Research Program · Chuzhou City Health and Medical Research Project

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