DataVXACS Applied Nano MaterialsPaper
journal article·2023-10-13

Nanomicelle-Based Redox-Responsive Dual-Prodrug for Synergistic Breast Cancer Chemo-Immunotherapy

Liuwei Zhang, Haonan Zheng, Hongyan Cui, Xiaolan Yin, Cheng Zhang, Yue Wang, Yan Zhao, Jiaqi Lin, Zheng Wang, Jingyun Wang, Qixian Chen

ACS Applied Nano Materials· Volume 6· Issue 19
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Source abstract

Abstract

One of the challenges in antitumor therapy is the precise delivery of the therapeutic agent to cancerous cells. The delivery of chemotherapy agents can benefit from nanoformulation of prodrugs, which integrates the benefits of nanotechnology and prodrugs, including enhanced drug loading, increased drug bioavailability, and targeted accumulation within cancerous cells. In this work, we designed a redox-responsive polymeric dual-prodrug nanocarrier, PL-ss-(C&J), for codelivery of a potent chemotherapeutic camptothecin (CPT) and an immune checkpoint inhibitor JQ1. Further investigations confirmed that the developed nanomedicine was able to respond to the highly reductive environment within tumor cells. Additionally, due to their quick reactions to the intracellular reducing microenvironment, cytotoxic CPT and JQ1 were simultaneously activated and released, exhibiting significant cytotoxicity. This dual-prodrug activation approach also demonstrated high efficiency in inhibiting tumor growth with satisfactory biocompatibility, pharmacokinetics, and safety in vivo . These results indicated that this type of redox-sensitive dual-prodrug codelivery system based on polymeric prodrug nanomicelles would be a promising technology in chemotherapy and immunotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Cancer therapeutics and mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, Dalian, Liaoning 116024, P. R. China

School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, Dalian, Liaoning 116024, P. R. China

Department of Gastric Surgery, Cancer Hospital of Dalian University of Technology, No. 44 Xiaoheyan Road, Shenyang, Liaoning 110042, P. R. China

Provincial Key Laboratory of Interdisciplinary Medical Engineering for Gastrointestinal Carcinoma, Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Shenyang, Liaoning 110042, P. R. China

Department of Gastric Surgery, Cancer Hospital of China Medical University, No. 44 Xiaoheyan Road, Shenyang, Liaoning 110042, P. R. China

China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, P. R. China

Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, Zhejiang 314100, P. R. China

Funding

National Key Research and Development Program of China · Dalian University of Technology · National Natural Science Foundation of China · Department of Health of Zhejiang Province · Liaoning Cancer Hospital and Institute · Shenyang Science and Technology Program · Liaoning Livelihood of the People Science and Technology

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