DataVXACS Applied Nano MaterialsPaper
journal article·2022-10-28

Iron Nanowires Coated with Metal–Organic Frameworks for Cell-Type-Specific Multimodal Therapy

Mram Z. Alyami, Yanyan Li, Niketan Patel, Walaa Baslyman, Othman Alahmed, Nouf A. Alsharif, Jenna Sleiman, Jurgen Kosel, Jasmeen S. Merzaban, Niveen M. Khashab

ACS Applied Nano Materials· Volume 5· Issue 10
Publisher page
Source abstract

Abstract

Targeted therapy has the potential to revolutionize medical approaches to bring us closer to an effective personalized therapy model. In this work, we developed homologous-targeted magnetic nanowires coated with biologics-loaded zeolitic imidazolate frameworks and cellular membranes (ZNWs) to provide an increased therapeutic potential both in vitro and in vivo. In vitro, the uncoated ZNWs combined with laser treatment reduced cancer cell viability by 34.6%, whereas the coated ZNWs combined with laser treatment reduced cancer cell viability by 45.91%. In vivo, ZNWs accumulated selectively in MCF-7 cancer cells and maintained a high intensity for up to 120 h, which reduced tumor growth significantly. Combining gene and tumor ablation treatment with the homologous targeting ability of ZNWs resulted in about 73% cell death. We believe that using such an assembled coating to camouflage delivery vehicles has effective outcomes in terms of improved targeting and therapeutic efficiency and should be studied further for medical translation.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Smart Hybrid Materials (SHMs) Laboratory, Chemistry program, Physical Science and Engineering Division, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia

Cell Migration and Signaling Laboratory, Bioscience Program, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia

Red Sea Research Center (RSRC), Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia

Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia

The KAUST School, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia

Sensor Systems Division (SeS), Silicon Austria Laboratories (SAL), Villach 9524, Austria

Funding

King Abdullah University of Science and Technology

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