DataVXACS Applied Nano MaterialsPaper
journal article·2022-12-23

Time-Resolved Study on Self-Assembling Behavior of PEGylated Gold Nanoparticles in the Presence of Human Serum Albumin: A System for Nanomedical Applications

Neda Iranpour Anaraki, Marianne Liebi, Kamran Iranshahi, Clément Blanchet, Peter Wick, Antonia Neels

ACS Applied Nano Materials· Volume 5· Issue 12
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Source abstract

Abstract

The combination of a microfluidic approach for synchrotron-based dynamic (early structural changes) with lab-based static small-angle X-ray scattering (SAXS) measurements (longer time scale) allows qualifying nanoparticle (NP) systems for their use in nanomedicine. Time-resolved in situ investigations are performed on self-assembly and colloidal behavior of 5 nm PEGylated (polyethylene glycol) gold NPs in different media. SAXS methods combined with a micromixing fluidic system are used to observe the early stage of NP interactions. Dynamic measurements cover a time range from 1 to 100 s after mixing thoroughly, while static measurements complete the study for up to 10 days after sample preparation. These NPs, after mixing with saline solution (0.9% NaCl solution), self-assemble in 3D ordered domains. The NPs also show this ordering in the presence of human serum albumin (HSA) molecules. It is shown that, although the presence of protein molecules slows down the NP self-assembling process, these molecules improve the long-term colloidal stability of the ordered domains probably via interpolymer complexation between PEG and HSA molecules.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Surfactants and Colloidal Systems · Electrostatics and Colloid Interactions · Protein Interaction Studies and Fluorescence Analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for X-ray Analytics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland

Laboratory of Particles-Biology Interactions, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland

Department of Chemistry, University of Fribourg, Chemin du Musée 9, Fribourg 1700, Switzerland

Laboratory for Biomimetic Membranes and Textiles, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen 9014, Switzerland

Department of Environmental Systems Science, Swiss Federal Institute of Technology, ETH-Zurich, Zurich 8092, Switzerland

European Molecular Biology Laboratory, Notkestrasse 85, Hamburg 22603, Germany

Funding

Competence Centre for Materials Science and Technology · Bundesbeh?rden der Schweizerischen Eidgenossenschaft

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