journal article·2021-12-24

Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Ji-wook Kim, Jiyong Cheong, Hayeon Cheong, Jun Geol Yoon, Joon-Yong Jung, Jae-Hyun Lee, Tae-Hyun Shin

ACS Applied Nano Materials· Volume 4· Issue 12
Publisher page

Abstract

We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Lanthanide and Transition Metal Complexes · Nanoparticle-Based Drug Delivery · Advanced MRI Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Inventera Pharmaceuticals Inc., Seoul 08507, Republic of Korea

Graduate Program of NanoBiomedical Engineering, Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea

Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

Department of Radiology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea

Institute for Basic Science (IBS) Center for Nanomedicine, Seoul 03722, Republic of Korea

Institute of Radiological Science, Yonsei University, Seoul 03722, Republic of Korea

Funding

Tech Incubator Program for Startup Korea funded by the Ministry of SMEs and Startups · National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT · Government-funded Technology Commercialization Program through the Korea Institute for Advancement of Technology (KIAT) funded by the Ministry of Trade, Industry and Energy (MOTIE)

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