DataVXACS Applied Nano MaterialsPaper
journal article·2022-02-25Open access

Gd3+-Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging

Raphaël De Matos, Adrian Gheata, Gabriel Campargue, Jérémy Vuilleumier, Laura Nicolle, Katarzyna Pierzchala, Ileana Jelescu, Fiorella Lucarini, Ivan Gautschi, Florian Riporto, Ronan Le Dantec, Yannick Mugnier, Anne-Sophie Chauvin, Marinella Mazzanti, Davide Staedler, Dario Diviani, Luigi Bonacina, Sandrine Gerber-Lemaire

ACS Applied Nano Materials· Volume 5· Issue 2
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Source abstract

Abstract

Harmonic nanoparticles (HNPs) have emerged as appealing exogenous probes for optical bioimaging due to their distinctive features such as long-term photostability and spectral flexibility, allowing multiphoton excitation in the classical (NIR-I) and extended near-infrared spectral windows (NIR-II and -III). However, like all other optical labels, HNPs are not suitable for whole-body imaging applications. In this work, we developed a bimodal nonlinear optical/magnetic resonance imaging (MRI) contrast agent through the covalent conjugation of Gd(III) chelates to coated lithium niobate HNPs. We show that the resulting nanoconjugates exert strong contrast both in T1-weighted MRI of agarose gel-based phantoms and in cancer cells by harmonic generation upon excitation in the NIR region. Their capabilities for dual T1/T2 MRI were also emphasized by the quantitative mapping of the phantom in both modes. The functionalization protocol ensured high stability of the Gd-functionalized HNPs in a physiological environment and provided a high r1 relaxivity value per NP (5.20 × 105 mM–1 s–1) while preserving their efficient nonlinear optical response.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Group for Functionalized Biomaterials, EPFL SB ISIC SCI-SB-SG, Station 6, CH-1015 Lausanne, Switzerland

Department of Applied Physics, Université de Genève, 22 Chemin de Pinchat, 1211 Genève 4, Switzerland

Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland

Neurometabolic Unit, Service of Clinical Chemistry, University Hospital of Lausanne, CH-1015 Lausanne, Switzerland

Animal Imaging and Technology, Center for Biomedical Imaging, EPFL, CH-1015 Lausanne, Switzerland

Faculty of Biology and Medicine, Department of Biomedical Sciences, Université de Lausanne, CH-1015 Lausanne, Switzerland

Université Savoie Mont-Blanc, SYMME, F-74000 Annecy, France

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Group of Coordination Chemistry, EPFL SB ISIC SCI-SB-MM, Station 6, CH-1015 Lausanne, Switzerland

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung · European Regional Development Fund

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