Reusable Immobilized Iron(II) Nanoparticle Precatalysts for Ligand-Free Kumada Coupling
Source abstract
Abstract
A nanoparticle (NP)-based precatalyst has been developed for organic synthesis: sulfur-modified Au-supported Fe (SAFe). The SAFe was easily prepared through a three-step procedure involving simultaneous in situ metal NP and nanospace organization (PSSO). This method avoids the need for preformed templates for immobilizing and stabilizing the metal nanoparticles. On account of the relative safety and enormous earth abundance of iron, SAFe potentially represents an ideal precatalyst for carbon–carbon bond-forming cross-coupling reactions. As such, it has been applied as a precatalyst to Kumada coupling under ligand-free conditions, proving to be capable of being recycled and used repeatedly for this reaction. Analysis of SAFe and of reaction mixtures suggested that the active species in these reactions are produced in situ by assemblies of iron-based NPs.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Catalytic Cross-Coupling Reactions · Catalytic C–H Functionalization Methods · Sulfur-Based Synthesis Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565-0871, Japan
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.
Japan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
The Institute of Scientific and Industrial Research, Osaka University, Mihoga-oka, Ibaraki, Osaka 567-0047, Japan
Faculty of Pharmaceutical Sciences, Hokkaido University, Kuta-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan
Funding
Engineering and Physical Sciences Research Council · Japan Agency for Medical Research and Development · Japan Science and Technology Agency · Japan Society for the Promotion of Science
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