Single-Crystal to Single-Crystal Transformation of Metal–Organic Framework Nanoparticles for Encapsulation and pH-Stimulated Release of Camptothecin
Source abstract
Abstract
The phenomenon of single-crystal to single-crystal transformation and the performance change along with the transformation have been widely discovered, whereas the efficient utilization of the crystal transformation process is less reported. Herein, we present an interesting thermally driven single-crystal to single-crystal transformation of HNU-43. During transformation, the effective encapsulation of camptothecin (CPT) has been achieved as CPT-HNU-43 converts into CPT-HNU-43(T), which cannot directly encapsulate CPT owing to the small channel size of HNU-43(T). Following the successful packaging, the CPT can be triggered to gradually release as pH = 6.0 which is quite close to the acid environment of cancer cells. Furthermore, CPT-HNU-43(T) nanoparticles show excellent biocompatibility, and the cancer cells can be effectively inhibited through the release of CPT.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Nanoplatforms for cancer theranostics · MXene and MAX Phase Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Advanced Materials of Tropical Island Resources, Ministry of Education, School of Science, Hainan University, Haikou 570228, China
School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China
School of Materials Science and Engineering, National Institute for Advanced Materials, Tianjin Key Laboratory of Metal and Molecule-Based Material Chemistry, Nankai University, Tianjin 300350, China
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China
Funding
Hainan University · National Natural Science Foundation of China · Opening Project of Key Laboratory of Polyoxometalate Science of Ministry of Education
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