Cobalt Phosphide Nanorods with Controlled Aspect Ratios as Synergistic Photothermo-Chemotherapeutic Agents
Source abstract
Abstract
Polydopamine-capped cobalt phosphide nanorods (Co2P@PDA NRs) with six aspect ratios (ARs) from 1.4 to 10 are synthesized by a one-step thermal decomposition and microemulsion method. The NRs with AR ∼ 6.4 show good dispersibility in physiological solutions, exhibiting an outstanding near-infrared (NIR) photothermal performance because of a high molar extinction coefficient of 13.08 L g–1 cm–1 at 980 nm, excellent photostability, a photothermal conversion efficiency (PCE) of ∼64%, and no obvious cytotoxicity to various types of cells. Coupled with NIR excitation, folic acid conjugation to the doxorubicin-loaded NRs (AR ∼ 6.4) helped them in securing targeted and controlled drug release to the cancer cells. The synergistic photochemothermal property of Co2P@PDA NRs offers itself as a worthy candidate in tumor theranostic applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, India
Funding
Council of Scientific and Industrial Research · Science and Engineering Research Board
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