Hydrogen-Peroxide-Independent Chemodynamic Therapy via Docosahexaenoic-Acid-Hydroperoxide-Rich-Cytomembrane-Coated Magnetic Nanoparticles

In tumor therapy, tactics for producing reactive oxygen species (ROS) are already being employed to disrupt the balance of redox equilibrium in cells and cause cell death. Among these, chemodynamic therapy (CDT) is an ingenious means to produce ROS via the Fenton reaction. The insufficiency in the tumor site or lability of in vivo administration of hydrogen peroxide has posed significant obstacles to the applications of CDT. Herein, we report docosahexaenoic acid hydroperoxide (D-OOH)-rich-cytomembrane-coated magnetic nanoparticles (MNP@D-OOH) for hydrogen-peroxide-independent CDT. D-OOH is facile to incorporate into the cytomembrane for efficient administration in vivo with little risk of leakage or alteration. In the tumor acid microenvironment, the MNPs decompose into Fe 2+, which can react with D-OOH to produce ROS just like Fenton reaction. This study offers beneficial insights for the clinical transformation of CDT.