DataVXACS Applied Nano MaterialsPaper
journal article·2024-07-26

Rare-Earth Metal-Based Nanosystems for Facilitating Neural Stem Cell Differentiation into Neurons and Enhancing Axonal Stability

Yuan Zhang, Zhibo Zheng, Jun Gao, Xinjie Bao, Wenjing Zhang, Lei Liu, Yulong Sun, Yongning Li

ACS Applied Nano Materials· Volume 7· Issue 14
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Source abstract

Abstract

Overcoming neural injury and facilitating effective repair pose considerable challenges in the field of neural rehabilitation, characterized by extensive disability and limited recovery rates. A critical aspect of reconstructing a functional nervous system revolves around the successful development of operational axons. In our investigation of rare-earth metal-based upconversion nanoparticles (UCNPs), we have discovered their ability to induce the differentiation of PC-12 cells into neurons. Expanding our inquiry into the implications of UCNPs in neural rehabilitation, we have also applied them in primary mouse neurogenesis, resulting in a significant increase in both neural length and quantity. Furthermore, when used during the induction of primary neural stem cells (NSCs), UCNP treatment has shown a dual effect: it enhances the expression of the neuronal marker TUBB3 while simultaneously inhibiting differentiation into astrocytes. This multifaceted impact was sustained in a prolonged neural sphere differentiation experiment, where UCNPs notably enhance the stability of neuronal axons and facilitate the establishment of intercellular connections. In summary, at the cellular level, introducing UCNPs not only promotes neuronal differentiation in NSCs but also sustains axonal growth, stability, and the formation of intercellular connections. These collective findings highlight the significant potential of UCNPs in advancing the frontiers of neural rehabilitation.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Neuroscience and Neural Engineering · Anesthesia and Neurotoxicity Research · Neurogenesis and neuroplasticity mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China

State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China

Department of Thoracic Surgery, Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, China

School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China

Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

University of Chinese Academy of Sciences, Beijing 100049, China

Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Macquarie Park, NSW 2109, Australia

Funding

Ministry of Science and Technology of China · Project for Young Scientists in Basic Research of the Chinese Academy of Sciences · National Natural Science Foundation of China

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