DataVXACS Applied Nano MaterialsPaper
journal article·2022-05-27

Using Gradient Magnetic Fields to Control the Size and Uniformity of Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Kun Ma, Ze Wang, Tongxiang Tao, Shuai Xu, Sajid ur Rehman, Xu Yan, Jun Fang, Ruiguo Chen, Hui Wang, Xin Zhang, Can Xie, Yang Lu, Qingyou Lu, Junfeng Wang

ACS Applied Nano Materials· Volume 5· Issue 5
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Source abstract

Abstract

The size and uniformity of magnetic nanoparticles are essential for biomedical performance. In this study, we successfully controlled the size and uniformity of magnetic nanomaterials by applying gradient magnetic fields during the solvothermal method. This regulation method conforms to the following laws: the size of the synthesized magnetic nanoparticles (MNPs) is smaller when the applied magnetic field is stronger, and the synthesized uniformity is better when the product of the applied field and its gradient is greater. In vitro and in vivo magnetic resonance imaging experiments show that magnetic field treatment resulted in uniform MNPs of 4.5 nm, which can significantly improve the T1 contrast performance. We further propose a dynamic process of field-induced reconfiguration for reverse micelles (re-micelles) to analyze how the gradient magnetic field affects MNP synthesis.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Iron oxide chemistry and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China

University of Science and Technology of China, Hefei 230036, Anhui, P. R. China

School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, Anhui, P. R. China

Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, Anhui, P. R. China

Funding

National Natural Science Foundation of China · National Science and Technology Major Project · Hefei Science Center, Chinese Academy of Sciences · Alliance of International Science Organization

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