journal article·2025-08

Carbon-based nanostructure drug delivery systems and their biologic applications – a review

Hale Alvandi, Anahid Shafie, Fatemeh Najafi, Mahdi Sabzini, Mohammad Mashayekhi, Sahand Hedayati Omami, Mohammad Mahdi Eskandarisani, Shamim Dashti, Alireza Javanmard, Mohammadreza Tajik, Stefan Bräse, Ahmad Reza Farmani

Carbon Letters· Volume 35· Issue 4
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OpenAlex topics: Graphene and Nanomaterials Applications · Fullerene Chemistry and Applications · Carbon and Quantum Dots Applications

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References (100+)

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1. Torrice M (2016) Does nanomedicine have a delivery problem? ACS Publications10.1021/acscentsci.6b00190 ↗
2. Kazemzadeh H, Mozafari M (2019) Fullerene-based delivery systems. Drug Discov Today 24(3):898–90510.1016/j.drudis.2019.01.013 ↗
3. Jampilek J, Kralova K (2021) Advances in drug delivery nanosystems using graphene-based materials and carbon nanotubes. Materials 14(5):105910.3390/ma14051059 ↗
4. Yang K, Feng L, Liu Z (2016) Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy. Adv Drug Deliv Rev 105:228–24110.1016/j.addr.2016.05.015 ↗
5. Yang K, Feng L, Liu Z (2015) The advancing uses of nano-graphene in drug delivery. Expert Opin Drug Deliv 12(4):601–61210.1517/17425247.2015.978760 ↗
6. Liu H et al (2017) Carbon nanostructures in biology and medicine. J Mater Chem B 5(32):6437–645010.1039/C7TB00891K ↗
7. Henna T et al (2020) Carbon nanostructures: the drug and the delivery system for brain disorders. Int J Pharm 587:11970110.1016/j.ijpharm.2020.119701 ↗
8. Rao N, Singh R, Bashambu L (2021) Carbon-based nanomaterials: synthesis and prospective applications. Mater Today Proc 44:608–61410.1016/j.matpr.2020.10.593 ↗
9. Dong H et al (2014) Surface-engineered graphene-based nanomaterials for drug delivery. J Biomed Nanotechnol 10(9):2086–210610.1166/jbn.2014.1989 ↗
10. Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70(1):7–30
11. Chen K et al (2019) A TRAIL-delivered lipoprotein-bioinspired nanovector engineering stem cell-based platform for inhibition of lung metastasis of melanoma. Theranostics 9(10):298410.7150/thno.31157 ↗
12. Tang L et al (2021) Advanced and innovative nano-systems for anticancer targeted drug delivery. Pharmaceutics 13(8):115110.3390/pharmaceutics13081151 ↗
13. Su Y et al (2018) On-demand versatile prodrug nanomicelle for tumor-specific bioimaging and photothermal-chemo synergistic cancer therapy. ACS Appl Mater Interfaces 10(45):38700–3871410.1021/acsami.8b11349 ↗
14. Zhang F et al (2016) A dual-targeting drug co-delivery system for tumor chemo-and gene combined therapy. Mater Sci Eng, C 64:208–21810.1016/j.msec.2016.03.083 ↗
15. Inamuddin A, Mohammad A (2018) Applications of nanocomposite materials in drug delivery. Elsevier
16. Mei Y et al (2021) Reconstituted high density lipoprotein (rHDL), a versatile drug delivery nanoplatform for tumor targeted therapy. J Mater Chem B 9(3):612–63310.1039/D0TB02139C ↗
17. Augustine S et al (2017) Recent advances in carbon based nanosystems for cancer theranostics. Biomater Sci 5(5):901–95210.1039/C7BM00008A ↗
18. Harisa GI, Faris TM (2019) Direct drug targeting into intracellular compartments: Issues, limitations, and future outlook. J Membr Biol 252(6):527–53910.1007/s00232-019-00082-5 ↗
19. Kalakonda P, Kalakonda PB, Banne S (2021) Studies of electrical, thermal, and mechanical properties of single-walled carbon nanotube and polyaniline of nanoporous nanocomposites. Nanomater Nanotechnol 11:1847980421100114010.1177/18479804211001140 ↗
20. Orooji Y et al (2021) Large optical nonlinearity of the activated carbon nanoparticles prepared by laser ablation. Nanomaterials (Basel) 11(3):73710.3390/nano11030737 ↗
21. Lee DK et al (2022) Electrical and thermal properties of carbon nanotube polymer composites with various aspect ratios. Materials (Basel) 15(4):135610.3390/ma15041356 ↗
22. Kumara BN, Kalimuthu P, Prasad KS (2023) Synthesis, properties and potential applications of photoluminescent carbon nanoparticles: a review. Anal Chim Acta 1268:34143010.1016/j.aca.2023.341430 ↗
23. Qasim M, Clarkson AN, Hinkley SFR (2023) Green synthesis of carbon nanoparticles (CNPs) from biomass for biomedical applications. Int J Mol Sci 24(2):102310.3390/ijms24021023 ↗
24. Rauti R et al (2019) Properties and behavior of carbon nanomaterials when interfacing neuronal cells: how far have we come? Carbon 143:430–44610.1016/j.carbon.2018.11.026 ↗
25. Wibowo A et al (2024) Carbon dots in photodynamic therapy: the role of dopant and solvent on optical and photo-responsive properties. Chemistry 30(54):e20240088510.1002/chem.202400885 ↗
26. Mohammadi R et al (2022) Fluorescence sensing and imaging with carbon-based quantum dots for early diagnosis of cancer: a review. J Pharm Biomed Anal 212:11462810.1016/j.jpba.2022.114628 ↗
27. Zarepour A et al (2024) Innovative approaches for cancer treatment: graphene quantum dots for photodynamic and photothermal therapies. J Mater Chem B 12(18):4307–433410.1039/D4TB00255E ↗
28. Iravani S, Varma RS (2020) Green synthesis, biomedical and biotechnological applications of carbon and graphene quantum dots. A review. Environ Chem Lett 18(3):703–72710.1007/s10311-020-00984-0 ↗
29. Ge J et al (2014) A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation. Nat Commun 5:459610.1038/ncomms5596 ↗
30. Lin LS et al (2016) Dual-enhanced photothermal conversion properties of reduced graphene oxide-coated gold superparticles for light-triggered acoustic and thermal theranostics. Nanoscale 8(4):2116–212210.1039/C5NR07552A ↗
31. Wan Mohd Zawawi WFA et al (2021) Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor. Sci Rep 11(1):1027810.1038/s41598-021-89740-0 ↗
32. Li Z et al (2019) Recent advances in nanomaterials-based chemo-photothermal combination therapy for improving cancer treatment. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2019.0029310.3389/fbioe.2019.00293 ↗
33. Zhao L et al (2021) Recent advances in selective photothermal therapy of tumor. J Nanobiotechnol 19(1):33510.1186/s12951-021-01080-3 ↗
34. Silva TA et al (2017) Electrochemical biosensors based on nanostructured carbon black: a review. J Nanomater 2017(1):4571614
35. Saini D (2016) Synthesis and functionalization of graphene and application in electrochemical biosensing. Nanotechnol Rev 5(4):393–41610.1515/ntrev-2015-0059 ↗
36. Gao S et al (2024) Nanotechnological advances in cancer: therapy a comprehensive review of carbon nanotube applications. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2024.135178710.3389/fbioe.2024.1351787 ↗
37. Zare H et al (2021) Carbon nanotubes: smart drug/gene delivery carriers. Int J Nanomed 16:1681–170610.2147/IJN.S299448 ↗
38. Singh D, Ray S (2023) A short appraisal of nanodiamonds in drug delivery and targeting: recent advancements. Front Nanotechnol. https://doi.org/10.3389/fnano.2023.125964810.3389/fnano.2023.1259648 ↗
39. Moscariello P et al (2019) Unraveling in vivo brain transport of protein-coated fluorescent nanodiamonds. Small 15(42):190299210.1002/smll.201902992 ↗
40. Yu Y et al (2024) Hybrid cell membrane-coated nanoparticles for biomedical applications. Small Struct 5(5):230047310.1002/sstr.202300473 ↗
41. Mousavi SM et al (2021) 5—hybrid magnetic nanoparticles–carbonaceous nanomaterials (carbon nanotube/graphene). In: Ehrmann A et al (eds) Magnetic nanoparticle-based hybrid materials. Woodhead Publishing, pp 121–13810.1016/B978-0-12-823688-8.00024-7 ↗
42. Lee SS, Paliouras M, Trifiro MA (2023) Functionalized carbon nanoparticles as theranostic agents and their future clinical utility in oncology. Bioengineering (Basel) 10(1):10810.3390/bioengineering10010108 ↗
43. Ali T et al (2024) Healthcare challenges in LMICs: addressing antibiotic resistance threats, a call for comprehensive global solutions: an editorial. Int J Surg 110(5):3085–308710.1097/JS9.0000000000001165 ↗
44. Zhu X et al (2024) Antibiotic resistance and nanotechnology: a narrative review. Microb Pathog 193:10674110.1016/j.micpath.2024.106741 ↗
45. Ioannou P, Baliou S, Samonis G (2024) Nanotechnology in the diagnosis and treatment of antibiotic-resistant infections. Antibiotics 13(2):12110.3390/antibiotics13020121 ↗
46. Zhang J et al (2024) Nanotechnology-driven strategies to enhance the treatment of drug-resistant bacterial infections. Wiley Interdiscip Rev Nanomed Nanobiotechnol 16(3):e196810.1002/wnan.1968 ↗
47. Vikal A et al (2024) Nano revolution: harnessing nanoparticles to combat antibiotic-resistant bacterial infections. Curr Pharm Design. https://doi.org/10.2174/011381612833774924102108405010.2174/0113816128337749241021084050 ↗
48. Nishshankage K et al (2024) Current trends in antimicrobial activities of carbon nanostructures: potentiality and status of nanobiochar in comparison to carbon dots. Biochar 6(1):210.1007/s42773-023-00282-2 ↗
49. Girma A et al (2024) Antibacterial capabilities of metallic nanoparticles and influencing factors. Nano Select 5(12):e20240004910.1002/nano.202400049 ↗
50. Yakup NF, et al (2024) Unveiling the antibiofilm arsenal: a mini review on nanoparticles’ mechanisms and efficacy in biofilm inhibition. In: International conference on science technology and social sciences–physics, material and industrial technology (ICONSTAS-PMIT 2023). Atlantis Press.10.2991/978-94-6463-500-3_16 ↗
51. Wu S, Wells G, Gray KA (2024) Engineered nanomaterials exert sublethal bacterial stress at very low doses: effects of concentration, light, and media on cell membrane permeability. Sci Total Environ 948:17486110.1016/j.scitotenv.2024.174861 ↗
52. Makhado BP et al (2024) Unravelling the toxicity of carbon nanomaterials–From cellular interactions to mechanistic understanding. Toxicol In Vitro 100:10589810.1016/j.tiv.2024.105898 ↗
53. Tong C et al (2019) Daptomycin and AgNP co-loaded rGO nanocomposites for specific treatment of Gram-positive bacterial infection in vitro and in vivo. Biomater Sci 7(12):5097–511110.1039/C9BM01229J ↗
54. Ansari MJ et al (2022) Improved antibacterial activity of sulfasalazine loaded fullerene derivative: computational and experimental studies. J Mol Liq 348:11808310.1016/j.molliq.2021.118083 ↗
55. Baig N, Kammakakam I, Falath W (2021) Nanomaterials: a review of synthesis methods, properties, recent progress, and challenges. Materials Advances 2(6):1821–187110.1039/D0MA00807A ↗
56. Riley PR, Narayan RJ (2021) Recent advances in carbon nanomaterials for biomedical applications: a review. Curr Opin Biomed Eng 17:10026210.1016/j.cobme.2021.100262 ↗
57. Madhurima VP, Kumari K, Jain PK (2024) Synthesis and study of carbon nanomaterials through arc discharge technique for efficient adsorption of organic dyes. Diam Relat Mater 141:11053810.1016/j.diamond.2023.110538 ↗
58. Ganash EA, Al-Jabarti GA, Altuwirqi RM (2019) The synthesis of carbon-based nanomaterials by pulsed laser ablation in water. Mater Res Express 7(1):01500210.1088/2053-1591/ab572b ↗
59. Whitener KE, Sheehan PE (2014) Graphene synthesis. Diamond Related Mater 46:25–3410.1016/j.diamond.2014.04.006 ↗
60. Manawi YM et al (2018) A review of carbon nanomaterials’ synthesis via the chemical vapor deposition (CVD) method. Materials 11(5):82210.3390/ma11050822 ↗
61. Henna T, Pramod K (2020) Graphene quantum dots redefine nanobiomedicine. Mater Sci Eng, C 110:11065110.1016/j.msec.2020.110651 ↗
62. Nedilko SG et al (2017) Structure and optical features of micro/nanosized carbon forms prepared by electrochemical exfoliation. Nanoscale Res Lett 12:1–910.1186/s11671-016-1770-5 ↗
63. Haque E et al (2018) Recent advances in graphene quantum dots: synthesis, properties, and applications. Small Methods 2(10):180005010.1002/smtd.201800050 ↗
64. Nersisyan HH, Lee JH (2024) Synthesis of carbon nanostructures in solid-flame: a review of opportunities and challenges. Carbon 226:11923810.1016/j.carbon.2024.119238 ↗
65. Zhou H et al (2024) Effect of NH3 addition on the preparation of nitrogen-doped carbon nanomaterials by flame synthesis method. Carbon Lett 34(9):2343–235510.1007/s42823-024-00760-y ↗
66. Zainal MT, Yasin MFM, Wahid MA (2016) Optimizing flame synthesis of carbon nanotubes: experimental and modelling perspectives. Jurnal Teknologi Sci Eng 78:8–4
67. Ibrahim MH et al (2023) Control of morphology and crystallinity of CNTs in flame synthesis with one-dimensional reaction zone. Beilstein J Nanotechnol 14:741–75010.3762/bjnano.14.61 ↗
68. Xi J et al (2021) A review of recent research results on soot: the formation of a kind of carbon-based material in flames. Front Mater. https://doi.org/10.3389/fmats.2021.69548510.3389/fmats.2021.695485 ↗
69. Kim C-D, Lee H-R, Kim HT (2016) Effect of NH3 gas ratio on the formation of nitrogen-doped carbon nanotubes using thermal chemical vapor deposition. Mater Chem Phys 183:315–31910.1016/j.matchemphys.2016.08.033 ↗
70. Russo C et al (2023) Fluorescent carbon dots synthesis in premixed flames: Influence of the equivalence ratio. Carbon 201:659–66610.1016/j.carbon.2022.09.061 ↗
71. Thangadurai TD et al (2022) A review on graphene quantum dots, an emerging luminescent carbon nanolights: healthcare and environmental applications. Mater Sci Eng B 278:11563310.1016/j.mseb.2022.115633 ↗
72. Hamzah N et al (2017) Rapid production of carbon nanotubes: a review on advancement in growth control and morphology manipulations of flame synthesis. J Mater Chem A 5(48):25144–2517010.1039/C7TA08668G ↗
73. Bhattacharjya D et al (2014) Nitrogen-doped carbon nanoparticles by flame synthesis as anode material for rechargeable lithium-ion batteries. Langmuir 30(1):318–32410.1021/la403366e ↗
74. Lekshmi GS et al (2021) Growth of rGO nanostructures via facile wick and oil flame synthesis for environmental remediation. Carbon Lett 31(4):763–77710.1007/s42823-021-00244-3 ↗
75. Chang BP, Gupta A, Mekonnen TH (2021) Flame synthesis of carbon nanoparticles from corn oil as a highly effective cationic dye adsorbent. Chemosphere 282:13106210.1016/j.chemosphere.2021.131062 ↗
76. Astefanei A, Núñez O, Galceran MT (2015) Characterisation and determination of fullerenes: a critical review. Anal Chim Acta 882:1–2110.1016/j.aca.2015.03.025 ↗
77. Sharma A, Das J (2019) Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine. J Nanobiotechnol 17(1):1–2410.1186/s12951-019-0525-8 ↗
78. Sagbas S, Sahiner N (2019) 22—carbon dots: preparation, properties, and application. In: Khan A et al (eds) Nanocarbon and its composites. Woodhead Publishing, USA, pp 651–67610.1016/B978-0-08-102509-3.00022-5 ↗
79. Zhao C et al (2020) Synthesis of graphene quantum dots and their applications in drug delivery. J Nanobiotechnol 18(1):1–3210.1186/s12951-020-00698-z ↗
80. Tian P et al (2018) Graphene quantum dots from chemistry to applications. Mater Today Chem 10:221–25810.1016/j.mtchem.2018.09.007 ↗
81. Hynes RJ et al (2019) 27—synthesis, properties, and characterization of carbon nanotube-reinforced metal matrix composites. In: Khan A et al (eds) Nanocarbon and its composites. Woodhead Publishing, USA, pp 805–83010.1016/B978-0-08-102509-3.00027-4 ↗
82. Pandey M et al (2024) A comprehensive review of recent developments in biomedical materials based on graphene-modified bio-nanocomposites. BioNanoScience 15(1):12510.1007/s12668-024-01757-7 ↗
83. Li J et al (2021) Promising graphene-based nanomaterials and their biomedical applications and potential risks: a comprehensive review. ACS Biomater Sci Eng 7(12):5363–539610.1021/acsbiomaterials.1c00875 ↗
84. Adetunji CO et al (2023) Chapter 12—graphene-based nanomaterials for targeted drug delivery and tissue engineering. In: Das S, Thomas S, Das PP (eds) Novel platforms for drug delivery applications. Woodhead Publishing, England, pp 277–28810.1016/B978-0-323-91376-8.00014-8 ↗
85. Battisti A, Samal SK, Puppi D (2023) Biosensing systems based on graphene oxide fluorescence quenching effect. Micromachines 14(8):152210.3390/mi14081522 ↗
86. Bellier N et al (2022) Recent biomedical advancements in graphene oxide- and reduced graphene oxide-based nanocomposite nanocarriers. Biomater Res 26(1):6510.1186/s40824-022-00313-2 ↗
87. Raslan A et al (2020) Graphene oxide and reduced graphene oxide-based scaffolds in regenerative medicine. Int J Pharm 580:11922610.1016/j.ijpharm.2020.119226 ↗
88. Mallakpour S, Soltanian S (2016) Surface functionalization of carbon nanotubes: fabrication and applications. RSC Adv 6(111):109916–10993510.1039/C6RA24522F ↗
89. Panwar N et al (2019) Nanocarbons for biology and medicine: sensing, imaging, and drug delivery. Chem Rev 119(16):9559–965610.1021/acs.chemrev.9b00099 ↗
90. de Andrade LRM et al (2024) Biomedical applications of carbon nanotubes: a systematic review of data and clinical trials. J Drug Deliv Sci Technol 99:10593210.1016/j.jddst.2024.105932 ↗
91. Wu H-C et al (2010) Chemistry of carbon nanotubes in biomedical applications. J Mater Chem 20(6):1036–105210.1039/B911099M ↗
92. Negri V et al (2020) Carbon nanotubes in biomedicine. Top Curr Chem (Cham) 378(1):1510.1007/s41061-019-0278-8 ↗
93. Liu J, Cui L, Losic D (2013) Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater 9(12):9243–925710.1016/j.actbio.2013.08.016 ↗
94. Liu J et al (2018) Graphene-based nanomaterials and their potentials in advanced drug delivery and cancer therapy. J Control Release 286:64–7310.1016/j.jconrel.2018.07.034 ↗
95. Dubey R et al (2021) Functionalized carbon nanotubes: synthesis, properties and applications in water purification, drug delivery, and material and biomedical sciences. Nanoscale Adv 3(20):5722–574410.1039/D1NA00293G ↗
96. Saharan R et al (2024) Beyond traditional hydrogels: the emergence of graphene oxide-based hydrogels in drug delivery. J Drug Deliv Sci Technol 94:10550610.1016/j.jddst.2024.105506 ↗
97. Li F et al (2025) A physical crosslinked pH-sensitive hydrogel based on hemicellulose/graphene oxide for controlled oral drug delivery. Int J Biol Macromol 289:13887510.1016/j.ijbiomac.2024.138875 ↗
98. Han C et al (2024) Applications of functionalized graphene oxide in drug delivery and biomedical imaging. Open Access Library J 11(10):1–9
99. Yadav P, Tyagi S, Negi S (2025) A review on the properties and application of carbon nanotubes as biological nanomotors: advantages and challenges. Arab J Sci Eng 50(1):29–4010.1007/s13369-024-09288-9 ↗
100. Turcheniuk K et al (2015) Plasmonic photothermal destruction of uropathogenic E. coli with reduced graphene oxide and core/shell nanocomposites of gold nanorods/reduced graphene oxide. J Mater Chem B 3(3):375–38610.1039/C4TB01760A ↗