Multifunctional Ti3C2@PDA/CuO2 Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy
Source abstract
Abstract
The escalating threat of antibiotic resistance has necessitated the development of innovative antibacterial strategies. In this study, a nanoplatform, Ti 3 C 2 @PDA/CuO 2, was engineered to exploit the synergistic effects of photothermal therapy (PTT), photodynamic therapy (PDT) and chemodynamic therapy (CDT) under near-infrared (NIR) light irradiation for the effective treatment of bacterial infections. Upon exposure to an 808 nm NIR laser and the application of hydrogen peroxide, the Ti 3 C 2 @PDA/CuO 2 nanoplatform demonstrated robust PTT, PDT and significantly photothermal-enhanced CDT activities. This multimodal therapeutic approach resulted in a pronounced antimicrobial response, as evidenced by in vitro assays that showed an extraordinary reduction in the viability of Escherichia coli and Staphylococcus aureus, with efficacies of 98.5% and 99.5%, respectively. Our findings contribute significant insights into the design of synergistic antibacterial strategies and offer a promising avenue for the development of advanced antimicrobial interventions.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · MXene and MAX Phase Materials · Advanced Photocatalysis Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Materials Science and Engineering, Hainan University, Haikou 570228, China
School of Chemical Engineering, Sichuan University of Science and Engineering, Zigong 643002, China
NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine & The Second Affiliated Hospital, Hainan Medical University, Haikou 571199, China
Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China
Funding
Natural Science Foundation of Hainan Province · National Natural Science Foundation of China · Hainan Province Science and Technology Special Fund · Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University
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