DataVXACS Applied Nano MaterialsPaper
journal article·2024-09-27

CoFe2O4 Nanoparticles Coated with Mesoporous Silica and Loaded with Naringin and Levofloxacin for Repair of Infectious Bone Defects

Wei Xiong, Yuxiang Zhou, Xiaolin Shi, Chaoyi Liang, Wenfang Deng, Lingmei Yuan, Guowen Qian, Cijun Shuai, Zhikui Zeng

ACS Applied Nano Materials· Volume 7· Issue 18
Publisher page
Source abstract

Abstract

The treatment of infective bone defects remains a considerable challenge for orthopedic surgeons, primarily due to the complexities of infection control and the unsatisfactory healing of bone tissue. To solve this challenge, we have designed core/shell nanoparticles to loaded with antibacterial and osteogenic agents. Specifically, magnetocaloric CoFe 2 O 4 (CF) nanoparticles loaded with naringin (NG) and coated with mesoporous silica (MS) were developed to construct NG-CF@MS nanoparticles. Subsequently, levofloxacin (LEV) was loaded into the MS coating, yielding NG-CF@MS-LEV nanoparticles capable of dual drug delivery. These nanoparticles were then incorporated into poly l-lactide (PLLA) powder to fabricate magnetically responsive scaffolds, which demonstrated enhanced osteogenesis and antibacterial activity under alternating magnetic field (AMF) conditions. Drug release studies showed a significant increase in NG and LEV release efficiency in the AMF setting, with a 337% increase in NG release and a 196% increase in LEV compared to non-AMF conditions. In vitro experiments further demonstrated that NG-CF@MS-LEV/PLLA scaffolds exhibited excellent osteogenic and antibacterial properties. Under the intervention of the AMF, the scaffolds displayed antibacterial rates of 98.67% and 99.38% against Escherichia coli and Staphylococcus aureus, respectively. Moreover, the scaffolds significantly promoted osteogenic differentiation and mineralization of mouse bone marrow mesenchymal stromal cells (mBMSCs), highlighting their potential as a promising therapeutic approach for repair of infected bone defects.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Jiangxi University of Chinese Medicine, Nanchang 330004, China

The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310052, China

Rehabilitation Department, Zhoushan Guanghua Hospital, Zhoushan, 316000, China

The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310052, China

Department of Orthopedics and Trauma, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China

Department of Ophthalmology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China

School of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, Nanchang 330013, China

Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China

State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China

College of Mechanical Engineering, Xinjiang University, Urumqi 830017, China

National Engineering Research Center for Manufacturing Technology of Traditional Chinese Medicine Solid Preparations, Jiangxi University of Chinese Medicine, Nanchang 330004, China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jiangxi Province · Guangdong Province Precision Manufacturing and Intelligent Production Education Integration Innovation Platform

References (47)

Show source-provided references
1. 10.1039/D3TB02069J10.1039/D3TB02069J ↗
2. 10.1056/NEJMoa171428410.1056/NEJMoa1714284 ↗
3. 10.1016/j.jconrel.2023.01.05810.1016/j.jconrel.2023.01.058 ↗
4. 10.1093/rb/rbad04610.1093/rb/rbad046 ↗
5. 10.1016/j.cej.2023.14453710.1016/j.cej.2023.144537 ↗
6. 10.1021/acsami.1c0216110.1021/acsami.1c02161 ↗
7. 10.1021/acsabm.3c0109110.1021/acsabm.3c01091 ↗
8. 10.1021/acsami.4c0598910.1021/acsami.4c05989 ↗
9. 10.1128/mbio.00415-1810.1128/mbio.00415-18 ↗
10. 10.1021/acsanm.1c0158810.1021/acsanm.1c01588 ↗
11. 10.1016/j.addr.2018.10.00410.1016/j.addr.2018.10.004 ↗
12. 10.1021/acsanm.3c0002210.1021/acsanm.3c00022 ↗
13. 10.1016/j.jconrel.2017.04.02810.1016/j.jconrel.2017.04.028 ↗
14. 10.1016/j.bioactmat.2021.09.02810.1016/j.bioactmat.2021.09.028 ↗
15. 10.1002/smll.20230694010.1002/smll.202306940 ↗
16. 10.1021/am507689a10.1021/am507689a ↗
17. 10.1039/D3TB01555F10.1039/D3TB01555F ↗
18. 10.18063/ijb.v7i2.34610.18063/ijb.v7i2.346 ↗
19. 10.1021/cm903837g10.1021/cm903837g ↗
20. 10.1016/j.inoche.2022.11003610.1016/j.inoche.2022.110036 ↗
21. 10.1016/j.moem.2017.10.00110.1016/j.moem.2017.10.001 ↗
22. 10.1016/j.apsusc.2018.01.27110.1016/j.apsusc.2018.01.271 ↗
23. 10.1007/s10973-008-9111-210.1007/s10973-008-9111-2 ↗
24. 10.1039/C4NJ01821D10.1039/C4NJ01821D ↗
25. 10.1021/jp810975v10.1021/jp810975v ↗
26. 10.1021/jp062646510.1021/jp0626465 ↗
27. 10.1016/j.arabjc.2024.10564710.1016/j.arabjc.2024.105647 ↗
28. 10.1016/j.cej.2019.03.07510.1016/j.cej.2019.03.075 ↗
29. 10.1016/j.molcata.2016.08.00710.1016/j.molcata.2016.08.007 ↗
30. 10.1007/s11356-018-3050-710.1007/s11356-018-3050-7 ↗
31. 10.1016/j.micromeso.2017.03.00510.1016/j.micromeso.2017.03.005 ↗
32. 10.1016/j.heliyon.2024.e2600510.1016/j.heliyon.2024.e26005 ↗
33. 10.1016/j.msec.2021.11238210.1016/j.msec.2021.112382 ↗
34. 10.1016/j.surfcoat.2019.12489810.1016/j.surfcoat.2019.124898 ↗
35. 10.1016/j.cej.2021.13279910.1016/j.cej.2021.132799 ↗
36. 10.1016/j.msec.2020.11081210.1016/j.msec.2020.110812 ↗
37. 10.1016/j.bioactmat.2021.11.03410.1016/j.bioactmat.2021.11.034 ↗
38. 10.1039/D3TB01533E10.1039/D3TB01533E ↗
39. 10.1016/j.carbpol.2021.11834110.1016/j.carbpol.2021.118341 ↗
40. 10.1021/acsami.8b0265610.1021/acsami.8b02656 ↗
41. 10.1016/j.actbio.2020.07.04410.1016/j.actbio.2020.07.044 ↗
42. 10.1016/j.bioactmat.2022.01.04810.1016/j.bioactmat.2022.01.048 ↗
43. 10.1016/j.msec.2021.11242510.1016/j.msec.2021.112425 ↗
44. 10.1039/D3TB02600K10.1039/D3TB02600K ↗
45. 10.1016/j.compositesb.2022.11042810.1016/j.compositesb.2022.110428 ↗
46. Zhao Y. · Mater. Des. · 2021 · 200
47. 10.1016/j.jcis.2023.10.13310.1016/j.jcis.2023.10.133 ↗