DataVXACS Applied Nano MaterialsPaper
journal article·2024-03-08

Carrier-free Nanodrug for the Chemical-Photodynamic Synergistic Treatment of Lung Cancer

Yingying Liao, Jiahui Ye, Luoyijun Xie, Longfei Mao, Jiangcun Wei, Chutong Liu, Jing Liang, Jianlong Zhou, Miaomiao Yuan, Zujie Qin

ACS Applied Nano Materials· Volume 7· Issue 5
Publisher page
Source abstract

Abstract

The theophylline derivative d17 is a candidate drug for nonsmall cell lung cancer (NSCLC) treatment previously developed by our group. However, it has the limitations of inadequate bioavailability, poor targeting, and insignificant therapeutic effect. Chemo-photodynamic synergistic therapy is a promising method of synergistic antitumor therapy. Herein, d17 and photosensitizer chlorin e6 (Ce6) were loaded into nanoparticles (NPs) via supramolecular self-assembly, which are self-assembled through π–π stacking and hydrogen bond interactions to form nanospheres with a size of about 85 nm and a surface charge of −33 mV. Compared with free Ce6, the d17–Ce6 NPs have good hydrophilicity and stability and can effectively accumulate in NSCLC tumor tissues due to the enhancement and retention effect. More significantly, the d17–Ce6 NPs can synergistically inhibit tumor growth compared with other treatment groups with no obvious toxicity. Taken together, the d17–Ce6 NPs may be an effective carrier-free nanodrug for the chemo-photodynamic synergistic treatment of NSCLC.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Cancer Research and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, China

Key Laboratory of Green Chemical Media and Reactions (Ministry of Education), Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, Henan, China

Guangxi International Zhuang Medicine Hospital, Guangxi University of Chinese Medicine, Nanning 530201, China

Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Funding

Guangxi Traditional Chinese Medicine Multidisciplinary Cross Innovation Team Project · High level Key Discipline of Traditional Chinese Medicine (Zhuang Pharmacy) Construction Project of the National Administration of Traditional Chinese Medicine · Guangxi University of Traditional Chinese Medicine "High level Talent Cultivation and Innovation Team" Funding Project · National Natural Science Foundation of China · Shenzhen Science and Technology Program

References (34)

Show source-provided references
1. 10.3322/caac.2170810.3322/caac.21708 ↗
2. 10.3322/caac.2166010.3322/caac.21660 ↗
3. 10.1097/JTO.000000000000063010.1097/JTO.0000000000000630 ↗
4. 10.1093/jnci/djm13510.1093/jnci/djm135 ↗
5. Koomägi R. · Anticancer Res. · 1999 · 19 · 4333
6. Cheng G. · Zhonghua Fuchanke Zazhi · 2000 · 35 · 87
7. Han B. · Chin. J. Tuberc. Respir. Dis. · 2002 · 25 · 727
8. 10.3109/1040923950908349110.3109/10409239509083491 ↗
9. 10.1016/j.bcp.2004.05.02610.1016/j.bcp.2004.05.026 ↗
10. Voynikov Y. · Pharmacia · 2014 · 61 · 12
11. 10.1021/acsomega.1c0042410.1021/acsomega.1c00424 ↗
12. 10.1007/s12272-012-0805-410.1007/s12272-012-0805-4 ↗
13. 10.1164/rccm.201302-0388PP10.1164/rccm.201302-0388PP ↗
14. 10.3389/fphar.2021.75367610.3389/fphar.2021.753676 ↗
15. 10.1016/j.drudis.2017.05.01410.1016/j.drudis.2017.05.014 ↗
16. 10.1016/j.ejmech.2018.08.05610.1016/j.ejmech.2018.08.056 ↗
17. 10.1016/j.bioorg.2020.10413310.1016/j.bioorg.2020.104133 ↗
18. 10.3390/molecules2611324910.3390/molecules26113249 ↗
19. 10.1111/cbdd.1320310.1111/cbdd.13203 ↗
20. 10.1016/j.ejmech.2018.04.00510.1016/j.ejmech.2018.04.005 ↗
21. 10.1021/acs.jmedchem.8b0016810.1021/acs.jmedchem.8b00168 ↗
22. 10.1016/j.ejmech.2017.10.04210.1016/j.ejmech.2017.10.042 ↗
23. 10.18632/oncotarget.1672310.18632/oncotarget.16723 ↗
24. 10.15171/jlms.2016.0710.15171/jlms.2016.07 ↗
25. 10.1016/j.jphotobiol.2020.11201510.1016/j.jphotobiol.2020.112015 ↗
26. 10.1039/c4pp00495g10.1039/c4pp00495g ↗
27. 10.1208/s12248-012-9339-410.1208/s12248-012-9339-4 ↗
28. 10.1021/acsami.5b0534710.1021/acsami.5b05347 ↗
29. 10.1007/s40139-021-00227-z10.1007/s40139-021-00227-z ↗
30. 10.1002/adhm.20220317710.1002/adhm.202203177 ↗
31. 10.1002/adma.20220717410.1002/adma.202207174 ↗
32. 10.1021/acsami.6b0241610.1021/acsami.6b02416 ↗
33. 10.1016/j.actbio.2022.05.02210.1016/j.actbio.2022.05.022 ↗
34. 10.1016/j.jconrel.2013.02.02010.1016/j.jconrel.2013.02.020 ↗