DataVXACS Applied Nano MaterialsPaper
journal article·2023-09-22

Self-Assembled Poly(rosmarinic acid) Nanoantioxidant for Enhanced Acute Liver Injury Treatment

Peng Tang, Huiyin Wu, Mengru Wang, Ruihan Zhang, Bin Liang, Xiaoli Li, Weilie Xiao

ACS Applied Nano Materials· Volume 6· Issue 18
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Source abstract

Abstract

Drug-based backboned polymers, especially poly(drug monomer) cross-linked with dynamic chemical bonds, have emerged as nanomedicines with reduced excipients. In this research, rosmarinic acid, a natural antioxidant with therapeutic potential for acute liver injury, was polymerized through borated ester bonds, and the linear poly(rosmarinic acid) (PRA) self-assembled into nanomedicines (named PRA NPs) through hydrophobic interactions in the presence of hydrophobic glycerol monooleate. Due to the fast and efficient liver accumulation, PRA NPs increased the antioxidation potential of rosmarinic acid and demonstrated better therapeutic effects in the in vivo treatment of acute liver injury. The findings of this study indicate that borate ester bond-mediated backbone poly(drug monomer) polymeric nanomedicines could provide a new approach for the processing of versatile nanomedicines.
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Research context

PolymersNanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Curcumin's Biomedical Applications · Neurological Disorders and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan; School of Pharmacy and School of Chemical Science and Technology; Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China

Funding

Yunnan University · Program for Changjiang Scholars and Innovative Research Team in University · National Natural Science Foundation of China · Yunnan Province · Yun Ling Scholar Project

References (29)

Show source-provided references
1. 10.1038/s41572-019-0105-010.1038/s41572-019-0105-0 ↗
2. 10.1016/j.biomaterials.2020.12057310.1016/j.biomaterials.2020.120573 ↗
3. 10.1016/j.cld.2013.07.00210.1016/j.cld.2013.07.002 ↗
4. 10.1586/17474124.2016.112775610.1586/17474124.2016.1127756 ↗
5. 10.3389/fphar.2021.80624910.3389/fphar.2021.806249 ↗
6. 10.1002/smll.20220789810.1002/smll.202207898 ↗
7. 10.1016/j.jconrel.2022.02.03410.1016/j.jconrel.2022.02.034 ↗
8. 10.1016/j.jcis.2023.05.03110.1016/j.jcis.2023.05.031 ↗
9. 10.1021/acsami.1c2296410.1021/acsami.1c22964 ↗
10. 10.1016/j.nantod.2020.10092510.1016/j.nantod.2020.100925 ↗
11. 10.1007/s40820-020-00550-x10.1007/s40820-020-00550-x ↗
12. 10.1016/j.addr.2020.06.01710.1016/j.addr.2020.06.017 ↗
13. 10.1002/adma.20210743410.1002/adma.202107434 ↗
14. 10.1002/adfm.20210095410.1002/adfm.202100954 ↗
15. 10.1002/adfm.20180864610.1002/adfm.201808646 ↗
16. 10.1002/adfm.20190785710.1002/adfm.201907857 ↗
17. 10.1021/acs.nanolett.0c0502810.1021/acs.nanolett.0c05028 ↗
18. 10.1039/D1CC02246F10.1039/D1CC02246F ↗
19. 10.1039/D1BM00881A10.1039/D1BM00881A ↗
20. 10.1007/s11426-019-9699-310.1007/s11426-019-9699-3 ↗
21. 10.1021/bm300328610.1021/bm3003286 ↗
22. 10.1039/b504634c10.1039/b504634c ↗
23. 10.1039/C6TB02833K10.1039/C6TB02833K ↗
24. 10.1080/13880209.2021.197405910.1080/13880209.2021.1974059 ↗
25. 10.1016/j.biopha.2019.10860010.1016/j.biopha.2019.108600 ↗
26. 10.1016/j.ijpharm.2009.10.01110.1016/j.ijpharm.2009.10.011 ↗
27. 10.1021/acsnano.1c0646010.1021/acsnano.1c06460 ↗
28. 10.1016/j.colsurfb.2023.11348910.1016/j.colsurfb.2023.113489 ↗
29. 10.7150/thno.3883410.7150/thno.38834 ↗