DataVXACS Applied Nano MaterialsPaper
journal article·2023-05-26

Active U11 Peptide Luminescent Gold Nanoclusters for Pancreatic Tumor Cell Targeting

Regina M. Chiechio, Rémi Le Guevél, Solène Ducarre, Hélène Solhi, Stéphanie Dutertre, Xavier Pinson, Jean-Pierre Bazureau, Olivier Mignen, Pascale Even-Hernandez, Paolo Musumeci, Célia Ravel, Maria Josè Lo Faro, Valérie Marchi

ACS Applied Nano Materials· Volume 6· Issue 10
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Source abstract

Abstract

The imaging of different intercellular regions is attracting growing interest in the fields of biosensing, drug delivery, and gene therapy for cancer treatment. We present the synthesis of luminescent gold nanoclusters (AuNCs), grafted with a PEGylated U 11 peptide derivative, for tumor recognition and their capacity to label the nucleus of pancreatic cancer cells. The short peptide named C 3 E 6 U 11, used to synthesize and functionalize gold nanoclusters, is composed of a tricysteine sequence with side-chain thiol residues as peptide anchors for the Au nanoclusters together with the recognition peptide domain (U 11 ). The active targeting red- or blue-emitting AuNCs can label pancreatic cancer cells and localize preferentially in the nucleus. The presence of U 11 at their surface facilitates their penetration into pancreatic cell nuclei. Finally, in vivo imaging experiments in early embryos and free-swimming juvenile zebrafish are also performed to evaluate their biodistribution.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanocluster Synthesis and Applications · Advanced Nanomaterials in Catalysis · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institut des Sciences Chimiques de Rennes ISCR, UMR CNRS 6226, University Rennes, Campus de Beaulieu, 35042 Rennes, France

Physics and Astronomy Department “E. Majorana”, University of Catania, 95123 Catania, Italy

ImPACcell Platform, Biosit, SFR UMS CNRS 3480, Inserm 018, University Rennes, Campus Villejean, 35043 Rennes, France

Institut de Recherche en Santé, Environnement et Travail IRSET, Inserm, UMR_S 1085, F-35000 Rennes, France

Microscopy Rennes Imaging Centre MRic, Biosit, SFR UMS CNRS 3480, Inserm 018, University Rennes, Campus Villejean, 35043 Rennes, France

Lymphocyte B & AutoImmunity LBAI, Inserm U1227, CHU Morvan, 29200 Brest, France

Service de Biologie de la Reproduction-CECOS, Centre Hospitalier Universitaire CHU Rennes, 35000 Rennes, France

Funding

Agence Nationale de la Recherche · Universit? di Catania · Ligue Contre le Cancer · Canc?rop?le Grand Ouest

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