journal article·2022-12-23

Merocyanine Complexes Coupled with Plasmonic Au Nanoparticles for Inhibiting Tau Aggregation

Yun-Chin Wu, Cheng-Yun Wu, Shu-Wei Tsai, Hsin-Jou Chen, Wang-Jing Liu, Duo Lin, Tianxun Gong, Ken-Tye Yong, Kien Voon Kong

ACS Applied Nano Materials· Volume 5· Issue 12
Publisher page

Abstract

Singlet oxygen (1O2) has been recently identified as the key mechanism for depressing β-amyloid (Aβ) accumulation and neurofibrillary tangles (NFTs). Slow cell internalization and short half-life of photosensitizing effects still impede the application of nanophotosensitizers for photodynamic therapy (PDT). The current major challenge of using spiropyran for PDT is the extremely short half-life of its ring-opened isomer, merocyanine. Merocyanine is the center of generation of 1O2. Here, we report that the complexation of spiropyran onto Au nanoparticles greatly enhances the stability of merocyanine (half-life is 91.6 h). Additionally, Au nanoparticles sharply decelerate the reversion of merocyanine back to spiropyran (a ring-closed form) by modifying the energy configuration of merocyanine, resulting in generation of a long-lived 1O2 phototherapy response (24 h) in the intracellular environment for depressing tau aggregation (a 32% reduction of NFT formation).
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Research context

OpenAlex topics: Photoreceptor and optogenetics research · Nanoplatforms for cancer theranostics · Photochromic and Fluorescence Chemistry

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan

Department of Earth and Life Science, University of Taipei, Taipei 100234, Taiwan

Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Digital Fujian Internet-of-Things Laboratory of Environment Monitoring, Fujian Normal University, Fuzhou 350007, China

State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Electronic Science and Engineering (National Exemplary School of Microelectronics), University of Electronic Science and Technology of China, Chengdu 610054, China

School of Biomedical Engineering, The University of Sydney, Sydney, New South Wales 2006, Australia

The University of Sydney Nano Institute, The University of Sydney, Sydney, New South Wales 2006, Australia

Funding

National Taiwan University · Ministry of Science and Technology, Taiwan

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