DataVXACS Applied Nano MaterialsPaper
journal article·2022-11-25

Au Nanorods Coated with pH-Responsive Polymers for Photothermal Therapy Against Multidrug-Resistant Bacteria

Yongjun Luo, Xiaoping Zhu, Jun Qian, Yiyi Yu, Jing Li, Zhiyong He, Suyan Duan, Honglei Guo, Xiangchun Shen, Qianqian Guo

ACS Applied Nano Materials· Volume 5· Issue 11
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Source abstract

Abstract

Overuse of antibiotics has led to an increased threat of drug-resistant pathogens and sustained chronic infections, suggesting an urgent need for effective strategies against drug-resistant bacterial infections. Herein, we developed au gold nanorods coated with pH-responsive polymers (GNR-DPArPEGMA) for photothermal therapy against multidrug-resistant bacteria. The size and zeta potential of GNR-DPArPEGMA was 78 nm and −37.96 mV, respectively. In subacidic conditions, the nanocomposite surface was positively (14.18 mV) charged, leading to better bacterial adhesion and antibacterial efficiency. The nanocomposites showed augmented in vitro photothermal efficiency up to 70 °C under 808 nm irradiation for 3 min, which further demonstrated an enhanced photothermal bacteria-killing efficiency. The in vivo assays showed that GNR-DPArPEGMA irradiated with near-infrared radiation could treat a drug-resistant Staphylococcus aureus-caused subcutaneous abscess and drug-resistant Pseudomonas aeruginosa-caused pneumonia while reducing the number of bacteria and attenuating inflammation in the infected sites. These results indicate that the nanocomposites could be used as a potential photothermal agent to combat drug-resistant bacterial infections in the future.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Drug Delivery Systems · Antimicrobial Peptides and Activities

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District 550025, Guizhou, China

The Department of Pharmacology of Materia Medical (the High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District 550025, Guizhou, China

Department of Pediatrics, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China

Funding

Guizhou Medical University · Major Scientific and Technological Special Project of Guizhou Province · National Natural Science Foundation of China · Chinese Medical Association · Double innovation talents of Jiangsu

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