DataVXACS Applied Nano MaterialsPaper
journal article·2018-12-28Open access

Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging

Kosuke Morishita, Shoji Ueki, Yasufumi Fuchi, Shuhei Murayama, Tomoyo Kaneko, Nozomi Narita, Shigeki Kobayashi, Go Hirai, Ichio Aoki, Satoru Karasawa

ACS Applied Nano Materials· Volume 1· Issue 12
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Source abstract

Abstract

As part of a series of investigations related to the construction of metal-free magnetic resonance imaging (MRI) contrast agents as alternatives to gadolinium agents, water-soluble biradicals, denoted as 1-AMP and 2-HEG, were prepared, in which two stable radicals were introduced to a ureabenzene framework. We found that 1-AMP possessed an amphiphilic side chain that consisted of an alkyl group and a hexaethylene glycol (HEG) chain, whereas 2-HEG possessed only an HEG chain. Accordingly, the biradicals showed self-assembly behavior due to multiple intermolecular interactions through which nanoparticles were formed in a water solution. Magnetic interaction took place in both biradicals, and the estimated interaction strength was J = 5.4 mT. Through MRI measurement, the water proton relaxivities, r1, were estimated to be 0.12 and 0.41 mM–1 s–1 for 1-AMP and 2-HEG, respectively; in other words, the r1 value for 2-HEG was approximately twice as high as that of monoradical-based contrast agents.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Lanthanide and Transition Metal Complexes · Magnetism in coordination complexes · Electron Spin Resonance Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan

Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University,1314-1 Shido, Sanuki City, Kagawa 769-2193, Japan

Faculty of Pharmaceutical Sciences, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida 194-8543, Japan

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba-city 263-8555, Japan

Department of Bioanalytical Chemistry, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

PRESTO, Japan Science and Technology Agency (JST), Kawaguchi 332-0012, Japan

Funding

Precursory Research for Embryonic Science and Technology

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