Dextran-Based Oxygen Nanobubbles for Treating Inner Retinal Hypoxia
Source abstract
Abstract
Central retinal artery occlusion (CRAO) is an obstruction of the retinal artery carrying oxygen to the cells in the inner retinal layers. This lack of oxygen may result in irreversible loss of sight if not treated within 24−36 h. We propose a dextran-based oxygen nanobubble (DONB) platform for intravitreal delivery of oxygen to rescue the inner retina from such ischemic damage. The size distribution of DONBs was 119.6 ± 44.9 nm and the zeta (ζ)-potential was −35.54 ± 10.54 mV. The DONBs were found to be stable in amber vials at 5 ± 3 °C for over 4 months and the formulation was not cytotoxic. The therapeutic efficacy of DONBs was first evaluated in retinal precursor cell lines which showed excellent recovery and then in a hypoxia/reperfusion rat eye model. Oxygen distribution measurements and histology indicated excellent recovery of the ganglion and inner retinal cell layers. Electroretinography exhibited normal retinal function. Our unique approach suggests a promising pathway to treat CRAO, a blinding condition for which no effective treatment exists.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Retinal and Optic Conditions · Retinal and Macular Surgery · Retinal Diseases and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States
Biomedical Research Centre (BRC), Mills Breast Cancer Institute, Carle Foundation Hospital, Urbana, Illinois 61801, United States
Vitreo-Retinal Surgery, Ophthalmology Department, Carle Foundation Hospital, Champaign, Illinois 61802, United States
Carle-Illinois College of Medicine, Champaign, Illinois 61820, United States
Cancer Centre at Illinois (CCIL), University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States
Nick Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States
Carl R. Woese Institute of Genomic Biology, University of Illinois, Urbana-Champaign, Illinois 61801, United States
Funding
University of Illinois at Urbana-Champaign
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